encyclopedia of medical concepts
ψ
ecarin
under Endopeptidases
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Endopeptidases
Definition
: A subclass of PEPTIDE HYDROLASES that catalyze the internal cleavage of PEPTIDES or PROTEINS.
Other names
Peptide Peptidohydrolases
Substance
CAS Registry & name
Categories
Source
Drugs
*
ecarin [ Echis carinatus prothrombin-activating proteins,echarin,prothrombin activation fragments, ecarin,prothrombin activator (Echis carinatus venom) ]
cleaves specifically Arg-Ile bond in prothrombin; procoagulant enzyme from Echis carinatus venom which converts prothrombin to thrombin
EC 3.4.99.27
*Endopeptidases
Enzyme Activation
Viper Venoms
Pharma Action
Fibrinolytic Agents
J Biochem (Tokyo):83(2):559;1978; J Biol Chem 254(18):8751;1879; Thromb Res 15(1-2):143;1979; Thromb Res 15(1-2):27;1979; Thromb Res 7(4):611;1975