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ATP Citrate (pro-S)-Lyase

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Definition: An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.      Other names Citrate Cleavage Enzyme; ATP Citrate Synthase; ATP Citrate Lyase; Synthase, ATP Citrate; Lyase, ATP-Dependent Citrate; Lyase, ATP Citrate; Cleavage Enzyme, Citrate; Citrate Synthase, ATP; Citrate Lyase, ATP-Dependent; Citrate Lyase, ATP; ATP Dependent Citrate Lyase; ATP-Dependent Citrate Lyase; ATP Citrate (pro-3S)-Lyase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ACLA protein, Arabidopsis  EC 2.3.3.8   *ATP Citrate (pro-S)-Lyase *Arabidopsis Proteins. Plant Physiol 2002 Oct;130(2):740-56
ACLB protein, Arabidopsis  EC 2.3.3.8   *ATP Citrate (pro-S)-Lyase *Arabidopsis Proteins. Plant Physiol 2002 Oct;130(2):740-56
SB 201076  0   *Chlorobenzenes ATP Citrate (pro-S)-Lyase/antagonists & inhibitors. Biochem J 1998 Aug 15;334(Pt 1):113-9
3-(carboxymethyl)-5-(6-(2,4-dichlorophenyl)hexyl)-3-hydroxytetrahydrofuran-2-one  0   *Furans ATP Citrate (pro-S)-Lyase/antagonists & inhibitors. J Med Chem 1998 Sep 10;41(19):3582-95
3-carboxy-11-(2,4-dichlorophenyl)-3,5-dihydroxyundecanoic acid  0   *Fatty Acids ATP Citrate (pro-S)-Lyase/antagonists & inhibitors. J Med Chem 1998 Sep 10;41(19):3582-95
2,2-difluorocitric acid  139182-83-5   *Citrates Aconitate Hydratase/antagonists & inhibitors ATP Citrate (pro-S)-Lyase/antagonists & inhibitors. Eur J Biochem 1991;202(3):889

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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