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Benzomorphans

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Definition: Morphine derivatives of the methanobenzazocine family that act as potent analgesics.  analgesics   
Examples Pentazocine; Phenazocine 		Other names Benzomorphan
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-((2R,6R,11R)-8-hydroxy-6,11-dimethyl-1,4,5,6-tetrahydro-2,6-methano-3-benzazocin-3(2H)-yl)-N-phenylpropanamide  0   *Benzomorphans Analgesics, Opioid. Life Sci. 2012 Jan 2;90(1-2):66-70
5,9-dimethyl-2'-hydroxy-2-(6-hydroxyhexyl)-6,7-benzomorphan hydrochloride  0   *Benzomorphans. Eur J Pharmacol 2007 Jul 2;566(1-3):88-93
8-amino-3-((tetrahydro-2-furanyl)methyl) benzomorphan  0   *Benzomorphans *Furans. Yao Xue Xue Bao. 2003 Oct;38(10):748-53
BIII 890 CL  0   *Benzomorphans. Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4944-9
2-benzyl-9-methyl-6,7-benzomorphan  0   *Benzomorphans Ligands. J Med Chem 1999 Nov 4;42(22):4621-9
BIII 277 CL  0   *Benzomorphans. J Pharmacol Exp Ther 1995 Dec;275(3):1382-9
2'-heptylcarbamoyloxy-2-methyl-6,7-benzomorphan  0   *Benzomorphans. Farmaco 1994 Nov;40(11):743-5
3-chlorallyl-2'-hydroxy-5,9-dimethyl-6,7-benzomorphan  3769-03-7   *Benzomorphans. J Pharm Sci 1993 Aug;82(8):821-8
2'-hydroxy-5,9-dimethyl-8,2-epoxyethano-6,7-benzomorphan  117016-26-9   *Benzomorphans. Acta Crystallogr C 1989;45(Pt 5):799
MR 1353  59203-73-5   *Benzomorphans. Neuropeptides 1985;5(4-6):323
2-(2-(4-bromoacetamidophenyl)ethyl)-5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphan  88467-32-7 Acetamide, 2-bromo-N-(4-(2-(1,4,5,6-tetrahydro-8-hydroxy-6,11-dimethyl-2,6-methano-3-benzazocin-3(2H)-yl)ethyl)phenyl)-, (2R-(2alpha,6alpha,11R*))  *Benzomorphans. J Neurochem 1983;41(6):1761
fluorophen  86495-14-9   *Benzomorphans Ligands. J Med Chem 1983;26(11):1643
Mr 1268  59203-74-6   *Benzomorphans.
5,9 alpha-diethyl-2'-hydroxybenzomorphan  73574-12-6 2,6-Methano-3-benzazocin-8-ol, 6,11-diethyl-1,2,3,4,5,6-hexahydro-, (2R-(2alpha,6alpha,11R*))  *Benzomorphans. J Med Chem 1981;24(11):1298
MRZ 2549  84774-03-8   *Benzomorphans. Life Sci 1981;29(12):1219
MR 2034  57236-85-8   *Benzomorphans. Life Sci 1981;29(12):1219
Mr 1452  72656-86-1   *Benzomorphans.
Pharma Action Narcotic Antagonists 		Arzneim Forsch 26(11):2009;1976; Arzneim Forsch 27(10):1884;1977; Neuropharmacology 17(6):427;1978; Neuropharmacology 1981;20(1):45
7,8-dihydroxy-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-1-ol  0   *Benzomorphans. Chem Pharm Bull (Tokyo) 1980;28(10):2862
bremazocine  75684-07-0 2,6-Methano-3-benzazocin-8-ol, 6-ethyl-1,2,3,4,5,6-hexahydro-3-((1-hydroxycyclopropyl)methyl)-11,11-dimethyl-, (2R)  *Benzomorphans.
Pharma Action Analgesics 		Life Sci 1980;27(11):971
MR 2266  56649-76-4   *Benzomorphans.
Pharma Action Narcotic Antagonists 		Arzneim Forsch 26(11):2009;1976; Life Sci 1980;27(11):971; Neuropharmacology 1981;20(1):45
cogazocine lactate  76283-00-6   *Benzomorphans. Toxicology 1980;16(3):193
2,5-dimethyl-9 alpha-ethyl-2'-hydroxy-6,7-benzomorphan  28623-78-1 (-)-11-ethyl-1,2,3,4,5,6-hexahydro-3,6-dimethyl- 2,6-methano-3-benzazocin-8-ol  *Benzomorphans. J Med Chem 22(7):889;1979
N-(2,4,5-trihydroxyphenethyl)normetazocine  62228-26-6 (2 alpha,6 alpha,11R*)-5-(2-(1,4,5,6-tetrahydro- 8-hydroxy-6,11-dimethyl-2,6-methano-3-benzazocin- 3(2H)-yl)ethyl)-1,2,4-benzenetriol  *Benzomorphans. J Med Chem 20(5):673;1977
2,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphan  57884-89-6 1,2,3,4,5,6-hexahydro-3,11-dimethyl-2,6-methano- 3-benzazocin-8-ol  *Benzomorphans. J Med Chem 19(2):259;1976
ID 1229  30802-84-7 1-(4-fluorophenyl)-4-(1,4,5,6-tetrahydro-8-hydroxy-6,11-dimethyl-2,6-methano-3-benzazocin-3(2H)-yl)-1-butanone  *Benzomorphans. Arch Int Pharmacodyn 1979;242(2):262; Arzneim Forsch 25(5):795;1975; Psychopharmacology 50:153;1976
GPA 1657  14578-59-7   *Benzomorphans. J Med Chem 21(7):600;1978
etazocine  34254-87-0 1,2,3,4,5,6-hexahydro-6,11-diethyl- 3-methyl-2,6-methano-3-benzazocin-8-ol  *Benzomorphans.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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