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Bicuculline

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Definition: An isoquinoline alkaloid obtained from Dicentra cucullaria and other plants. It is a competitive antagonist for GABA-A receptors.     
Pharmacological Action Convulsants; GABA-A Receptor Antagonists 		Other names 6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo(4,5-g)i
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
bicuculline methoxide  41544-46-1 1,3-Benzodioxole-4-carboxylic acid, 5-(hydroxy(5,6,7,8-tetrahydro-6-methyl-1,3-dioxolo(4,5-g)isoquinolin-5-yl)methyl)-, methyl ester  Bicuculline/*analogs & derivatives. J Neurosci Res 1982;8(4):657
bicuculline methobromide  66016-70-4   Bicuculline/*analogs & derivatives. Physiol Behav 1982;29(5):901
bicuculline methiodide  40709-69-1   Bicuculline/*analogs & derivatives. Exp Neurol 60(2):224;1978
bicuculline methochloride  38641-83-7   Bicuculline/*analogs & derivatives.
Pharma Action GABA Antagonists 		Br J Pharmacol 51(1):133;1974; Exp Brain Res 28(3-4):311;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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