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Clonidine

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Definition: An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.     
Pharmacological Action Adrenergic alpha-2 Receptor Agonists; Analgesics; Antihypertensive Agents; Sympatholytics 		Other names ST155; ST 155; Monohydrochloride, Clonidine; Monohydrobromide, Clonidine; M5041T; M 5041T; Hydrochloride, Clonidine; Dihydrochloride, Clonidine; ST-155; M-5041T; Klofenil; Klofelin; Isoglaucon; Hemiton; Gemiton; Dixarit; Clopheline; Clonidine Monohydrochloride; Clonidine Monohydrobromide; Clonidine HydrochlorideDrugs* : KAPVAY; JENLOGA; CLONIDINE; CATAPRES-TTS-1; CATAPRES-TTS-2; CATAPRES; CATAPRES-TTS-3; CLONIDINE HYDROCHLORIDE; DURACLON
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3,5-dichloro-4-(imidazolidin)-2-ylideneammonio benzoate dehydrate  0   Clonidine/*analogs & derivatives. Methods Find Exp Clin Pharmacol 2008 Apr;30(3):193-9
2,4,6-trifluorine clopheline  0   Clonidine/*analogs & derivatives. Eksp Klin Farmakol 1999 Nov-Dec;62(6):20-2
proxopheline  0   *Clonidine *Oxadiazoles Drug Combinations Glaucoma Ophthalmic Solutions. Vestn Oftalmol 1998 May-Jun;114(3):3-4
TH 91-22  0   Clonidine/*analogs & derivatives. J Cardiovasc Pharmacol 1997 Apr;29(4):499-507
TH 91-21  0   Clonidine/*analogs & derivatives. J Cardiovasc Pharmacol 1997 Apr;29(4):499-507
2,6-dimethylclonidine  59520-70-6   Clonidine/*analogs & derivatives. J Pharmacol Exp Ther 1992 Jun;261(3):1080-6
4-hydroxyclonidine  57101-48-1   Clonidine/*analogs & derivatives. Eur J Pharmacol 1989;160(2):201
clonidine-displacing substance  91432-88-1 Clonidine-displacing substance  Clonidine/*analogs & derivatives. Isr J Med Sci 1987;23(12):1194
St 93  56360-29-3   Clonidine/*analogs & derivatives. Indian J Physiol Pharmacol 1987;31(2):111
4-iodoclonidine  108294-53-7   Clonidine/*analogs & derivatives.
Pharma Action Affinity Labels 		J Med Chem 1987;30(7):1241
chlorethylclonidine  98086-36-3   Clonidine/*analogs & derivatives.
Pharma Action Adrenergic alpha-Antagonists ; Alkylating Agents 		Mol Pharmacol 1987;31(3):239
CBS 1276  95668-39-6 Benzaldehyde, 4-hydroxy-2-methyl-, (4,5-dihydro-1H-imidazol-2-yl)hydrazone, monohydrochloride  Clonidine/*analogs & derivatives. Biochem Pharmacol 1986;35(9):1511
KUM 32  28717-34-2   Clonidine/*analogs & derivatives. Biochem Pharmacol 1986;35(9):1511
4-azidoclonidine  99616-15-6   Clonidine/*analogs & derivatives. Eur J Pharmacol 1985;117(1):43
2-(2,6-dichlorophenyloxy)-2-imidazoline  0   Clonidine/*analogs & derivatives. Hypertension 1984;6(5 Pt 2):II-51
ST 1967  76833-40-4   Clonidine/*analogs & derivatives. Hypertension 1984;6(5 Pt 2):II-51
St 1965  53103-46-1 1H-Imidazole-2-methanol, alpha-(2,6-dichlorophenyl)-4,5-dihydro  Clonidine/*analogs & derivatives. J Auton Pharmacol 1983;3(3):185
clonidine 4-methylisothiocyanate  0   Clonidine/*analogs & derivatives. Eur J Pharmacol 1983;93(3-4):205
2-(6-(1,4-benzodioxanyl)amino)imidazoline maleate  87135-04-4 1H-Imidazol-2-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4,5-dihydro-, (Z)-2-butenedioate (1:1)  Clonidine/*analogs & derivatives. Eur J Pharmacol 1983;91(1):123
2-(3,4-dimethoxyphenylamino)imidazoline  87135-05-5 1H-Imidazol-2-amine, N-(3,4-dimethoxyphenyl)-4,5-dihydro-, monohydrochloride  Clonidine/*analogs & derivatives. Eur J Pharmacol 1983;91(1):123
2-(2,3,6-trichlorophenylimino)imidazolidine  82780-90-3   *Imidazolidines Clonidine/*analogs & derivatives. Br J Pharmacol 1983;78(3):479
2-(2,3-dichloro-6-methylphenylimino)imidazolidine  82801-84-1   Clonidine/*analogs & derivatives. Br J Pharmacol 1983;78(3):479
St 1913  52115-81-8   Clonidine/*analogs & derivatives. Pharmacology 1982;25(4):187
indanidine  81972-22-7 2H-Indazol-4-amine, N-(4,5-dihydro-1H-imidazol-2-yl)-2-methyl-, hydrochloride  Clonidine/*analogs & derivatives.
Pharma Action Adrenergic alpha-Agonists 		Br J Pharmacol 1982;75(3):549
clonidine 4-isothiocyanate  81913-29-3 1H-Imidazol-2-amine, N-(2,6-dichloro-4-isothiocyanatophenyl)-4,5-dihydro  Clonidine/*analogs & derivatives. Proc Natl Acad Sci USA 1982;79(5):1378
4-carboxyclonidine-methyl 3,5-dichlorotyrosine  75472-83-2 L-Tyrosine, N-(3,5-dichloro-4-((4,5-dihydro-1H-imidazol-2-yl)amino)benzoyl)-3,5-diiodo-, methyl ester  *Clonidine *Monoiodotyrosine. J Pharmacol Methods 1981;6(4):295
2-(2-methyl-4-chlorophenylamino)-2-imidazoline  4201-26-7   Clonidine/*analogs & derivatives. Agents Actions 1981;11(6-7):718
St 587  15327-38-5 1H-Imidazol-2-amine, N-(2-chloro-5-(trifluoromethyl)phenyl)-4,5-dihydro-, mononitrate  Clonidine/*analogs & derivatives. Life Sci 1981;28(18):2009
hydroxyphenacetyl aminoclonidine  76958-98-0 Benzeneacetamide, N-(3,5-dichloro-4-((4,5-dihydro-1H-imidazol-2-yl)amino)phenyl)-4-hydroxy  *Benzeneacetamides Clonidine/*analogs & derivatives. Eur J Biochem 1981;113(3):521
lofexidine  31036-80-3 1H-imidazole, 2-(1-(2,6-dichlorophenoxy)ethyl)-4,5-dihydro  Clonidine/*analogs & derivatives.
Pharma Action Antihypertensive Agents ; Narcotic Antagonists ; Adrenergic alpha-2 Receptor Agonists 		Pharmacol Biochem Behav 1980;12(4):573
N,N'-dimethylclonidine  41061-97-6 2,6-dichloro-N-(1,3-dimethyl-2-imidazolidinylidene)benzenamine  Clonidine/*analogs & derivatives. Br J Pharmacol 66(3):425P;1979
tizanidine  51322-75-9 2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)  Clonidine/*analogs & derivatives.
Pharma Action Analgesics ; Anticonvulsants ; Muscle Relaxants, Central ; Parasympatholytics ; Adrenergic alpha-2 Receptor Agonists 		Nervenarzt 48(7):351;1977; Nervenarzt 48(7):355;1977TIZANIDINE HYDROCHLORIDE; ZANAFLEX
alinidine  33178-86-8   Clonidine/*analogs & derivatives Cyclic Nucleotide-Gated Cation Channels.
Pharma Action Anti-Arrhythmia Agents ; Cardiovascular Agents 		Eur J Pharmacol 58(2):141;1979
apraclonidine  66711-21-5   Clonidine/*analogs & derivatives.
Pharma Action Adrenergic alpha-2 Receptor Agonists 		C R Soc Biol 286(11):909;1978; Life Sci 1979;25(9):769; Science 1980;207(4431):645IOPIDINE; APRACLONIDINE HYDROCHLORIDE
2-(2,6-dichlorophenylimino)piperimidine.HNO3  65955-46-6 N-(2,6-dichlorophenyl)-1,4,5,6-tetrahydro-2-pyrimidinamine, mononitrate  Clonidine/*analogs & derivatives. Pharmacology 16:106;1978
tolonidine  4201-22-3   Clonidine/*analogs & derivatives. Arzneim Forsch 25(10):1557;1975; Arzneim Forsch 25(11):1802;1975; Arzneim Forsch 25(12):1926;1975
St 363  23830-88-8 N-(2,4-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine, monohydrochloride  *Clonidine Isomerism.
ST 91  4751-48-8   Clonidine/*analogs & derivatives.
Pharma Action Adrenergic alpha-Agonists ; Parasympathomimetics 		Arzneim Forsch 28(2):260;1978; Eur J Pharmacol 43(4):333;1977; Naunyn Schmiedebergs Arch Pharmacol 291(2):175;1975; Neuropharmacology 1979;18(8-9):731
clonidine, chlorthalidone drug combination  0   *Chlorthalidone *Clonidine Drug Combinations.
Pharma Action Antihypertensive Agents 		CLORPRES; COMBIPRES; CLONIDINE HYDROCHLORIDE AND CHLORTHALIDONE

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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