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Cystathionine gamma-Lyase

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Definition: A multifunctional pyridoxal phosphate enzyme. In the final step in the biosynthesis of cysteine it catalyzes the cleavage of cystathionine to yield cysteine, ammonia, and 2-ketobutyrate. EC 4.4.1.1.  /defic: consider also CYSTATHIONINE /urine (IM) + AMINO ACID METABOLISM, INBORN ERRORS (IM)    Other names gamma-Cystathionase; Homoserine Dehydratase; Homoserine Deaminase; Cystine Desulfhydrase; Cysteine Desulfhydrase; Cystathionase; gamma-Lyase, Cystathionine; gamma Cystathionase; Desulfohydrolase, Cystine; Desulfhydrase, Cystine; Desulfhydrase, Cysteine; Dehydratase, Homoserine; Deaminase, Homoserine; Cystathionine gamma Lyase; Cystine Desulfohydrolase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cystalysin  EC 4.4.1.-   *Cystathionine gamma-Lyase. Infect Immun 1997 Aug;65(8):3231-8
MalY protein, E coli  140881-88-5   *Cystathionine gamma-Lyase *Repressor Proteins *Escherichia coli Proteins Aspartate Aminotransferases Maltose/metabolism. Eur J Biochem 1993 Jan15;211(1-2):373-6
CYS3 protein, S cerevisiae  EC 4.4.1.1   *Cystathionine gamma-Lyase *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1992 Apr;12(4):1568-77
propargylglycine  64165-64-6   *Alkynes Glycine/*analogs & derivatives Cystathionine gamma-Lyase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Biochem Pharm 27(24):2807;1978; Biochemistry 15(14):3070;1976; Biochemistry 16(11):2485;1977; Biochemistry 17(14):2864;1978; Biochemistry 17(26):5613;1978; Biochemistry 1979;18(21):4690; J Biochem 78:57;1975; J Biol Chem 1980;255(8):3487; J Chem Soc 95(18):6124;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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