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Dermotoxins

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Definition: Specific substances elaborated by plants, microorganisms or animals that cause damage to the skin; they may be proteins or other specific factors or substances; constituents of spider, jellyfish or other venoms cause dermonecrosis and certain bacteria synthesize dermolytic agents.  /antag permitted but consider also ANTITOXINS; coord IM with source of dermotoxin (IM or NIM); do not use for dermatoxicity of various chemicals & drugs (    Other names Epidermotoxins; Dermatotoxins
Substances having this pharmacologic action: Exfoliatins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
loxnecrogin protein, Loxosceles gaucho  0   *Spider Venoms *Insect Proteins Dermotoxins. J Protein Chem 2003 Feb;22(2);135-46
lyngbyatoxin C  133084-53-4 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 9-(1-ethenyl-5-hydroxy-1,5-dimethyl-3-hexenyl)-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S-(2R*,5R*,9(S*)))  *Lyngbya Toxins Dermotoxins Marine Toxins. J Nat Prod 1990;53(6):1593
lyngbyatoxin B  133084-52-3 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 9-(1-ethenyl-4-hydroxy-1,5-dimethyl-5-hexenyl)-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)  *Lyngbya Toxins Dermotoxins Marine Toxins. J Nat Prod 1990;53(6):1593
dermonecrotic toxin, Pasteurella multocida  0   *Bacterial Toxins Dermotoxins Pasteurella. Res Vet Sci 1987;42(2):232
5-methoxypsoralen  484-20-8 4-methoxy-7H-furo(3,2-g)(1)benzopyran-7-one  Methoxsalen/*analogs & derivatives Dermotoxins Dermatitis, Phototoxic.
Pharma Action Photosensitizing Agents 		Radiolbiologiia 19(6):833;1979
lyngbyatoxin A  70497-14-2 3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 9-(1-ethenyl-1,5-dimethyl-4-hexenyl)-1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)  *Lyngbya Toxins Dermotoxins Marine Toxins. Science 204(4039):193;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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