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Flumazenil

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Definition: A potent benzodiazepine receptor antagonist. Since it reverses the sedative and other actions of benzodiazepines, it has been suggested as an antidote to benzodiazepine overdoses.     
Pharmacological Action Antidotes; GABA Modulators 		Other names Flumazepil; Ro 151788; Ro 15 1788; Hoffman La Roche Brand of Flumazenil; Romazicon; Roche Brand of Flumazenil; Ro 15-1788; Lanexat; Hoffman-La Roche Brand of Flumazenil; AnexateDrugs* : FLUMAZENIL; ROMAZICON
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2'-fluoroflumazenil  0   Flumazenil/*analogs & derivatives Fluorine Radioisotopes. Nucl Med Biol 2003 Jul;30(5):521-7
5-(2'-fluoroethylflumazenil)  0   Flumazenil/*analogs & derivatives. Nucl Med Biol 2001 Oct;28(7):809-14
3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl) 7-bromo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5.alpha)-benzodiazepine  0   *Oxadiazoles Flumazenil Receptors, GABA-A/agonists. Eur J Nucl Med 1997 Oct;24(10):1261-7
5-(2'-fluoroethyl)flumazenil  143693-57-6   Flumazenil/*analogs & derivatives Fluorine Radioisotopes. Eur J Pharmacol 1992 Jul 21;218(1):109-15
ethyl 8-fluoro-5,6-dihydro-5-(3'-fluoropropyl)-6-oxo-4H-imidazol(1,5-a)(1,4)benzodiazepine-3-carboxylate  133368-71-5   Flumazenil/*analogs & derivatives. Int J Rad Appl Instrum (B) 1990;17(8):811
3'-fluoropropyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazol(1,5-a)(1,4)benzodiazepine-3-carboxylic acid  133368-73-7   Flumazenil/*analogs & derivatives. Int J Rad Appl Instrum (B) 1990;17(8):811
BD 623  132305-66-9 4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, 3-((7-nitro-4-benzofurazanyl)amino)propyl ester  Flumazenil/*analogs & derivatives 4-Chloro-7-nitrobenzofurazan/*analogs & derivatives. J Biol Chem 1990;265(36):22181
iomazenil  127396-36-5   Flumazenil/*analogs & derivatives Iodine Radioisotopes. Int J Rad Appl Instrum (B) 1989;16(8):759
Ro 15-3890  84378-44-9   Flumazenil/*analogs & derivatives. Int J Rad Appl Instrum (A) 1988;39(9):993

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