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Glutamate Decarboxylase

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Definition: A pyridoxal-phosphate protein that catalyzes the alpha-decarboxylation of L-glutamic acid to form gamma-aminobutyric acid and carbon dioxide. The enzyme is found in bacteria and in invertebrate and vertebrate nervous systems. It is the rate-limiting enzyme in determining GAMMA-AMINOBUTYRIC ACID levels in normal nervous tissues. The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15.      Other names Glutamate Carboxy-Lyase; Glutamate Carboxy Lyase; Decarboxylase, Glutamic Acid; Decarboxylase, Glutamate; Carboxy-Lyase, Glutamate; Acid Decarboxylase, Glutamic; Glutamic Acid Decarboxylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
GAD55, human  EC 4.1.1.15   *Glutamate Decarboxylase. J Immunother. 2005 Sep-Oct;28(5):438-48
glutamic acid decarboxylase 65 (524-543), mouse  EC 4.1.1.15   *Glutamate Decarboxylase *Peptide Fragments. J Immunol 2005 Sep 15;175(6):3621-7
black protein, Drosophila  EC 4.1.1.15   *Glutamate Decarboxylase *Drosophila Proteins. J Neurochem 1993 Oct;61(4):1291-301
glutamate decarboxylase 65 (202-221)  EC 4.1.1.-   *Glutamate Decarboxylase *Peptide Fragments. J Autoimmun 2004 Dec;23(4):311-21
GAD65 (217-236)  EC 4.1.1.-   *Glutamate Decarboxylase *Peptide Fragments. Diabetes 2001 Nov;50(11):2459-63
GAD65 (524-543)  EC 4.1.1.-   *Glutamate Decarboxylase *Peptide Fragments. Diabetes 2001 Nov;50(11):2459-63
glutamate decarboxylase 1  EC 4.1.1.15   *Glutamate Decarboxylase. Clin Exp Immunol 1999 Dec;118(3):349-56
glutamate decarboxylase 2  EC 4.1.1.15   *Glutamate Decarboxylase. Proc Natl Acad Sci U S A 1999 Oct 26;96(22):12911-6
gadA protein, E coli  EC 4.1.1.-   *Glutamate Decarboxylase *Membrane Proteins *Escherichia coli Proteins. Mol Microbiol 1999 Jun;32(6):1198-211
ERT D1 protein, Lycopersicon esculentum  EC 4.1.1.15   *Glutamate Decarboxylase *Plant Proteins. Plant Mol Biol 1995 Mar;27(6):1143-51
4-bromoisophthalic acid  6939-93-1   *Phthalic Acids Glutamate Decarboxylase/antagonists & inhibitors. Biochem Int 1991;23(5):915
N-gamma-glutamyldiaminopropionic acid  86860-76-6 beta-Alanine, D-2-amino-N-L-gamma-glutamyl  *Dipeptides Glutamate Decarboxylase/antagonists & inhibitors. J Neurochem 1983;41(1):244
(2RS,3E)-2-methyl-3,4-didehydroglutamic acid  71897-84-2 2-Pentenedioic acid, 4-amino-4-methyl-, (E)-(+-)  *Glutamates Glutamate Decarboxylase/antagonists & inhibitors. J Neurochem 32(5):1501;1979
aspartate-alpha-decarboxylase  EC 4.1.1.11   *Glutamate Decarboxylase. J Biol Chem 254(16):8074;1979
2-keto-4-pentenoic acid  20406-62-6   *Fatty Acids, Monounsaturated Glutamate Decarboxylase/antagonists & inhibitors. Biochem Pharmacol 27(1):1471;1978; Br J Pharmacol 63(2):381P;1978; J Neurochem 32(3):907;1979
pyridoxal phosphate gamma-glutamyl hydrazone  14520-50-4   Pyridoxal Phosphate/*analogs & derivatives Glutamate Decarboxylase/antagonists & inhibitors.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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