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GTP Cyclohydrolase

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Definition: (GTP cyclohydrolase I) or GTP 7,8-8,9-dihydrolase (pyrophosphate-forming) (GTP cyclohydrolase II). An enzyme group that hydrolyzes the imidazole ring of GTP, releasing carbon-8 as formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized. This is the first step in the synthesis of folic acid from GTP. EC 3.5.4.16 (GTP cyclohydrolase I) and EC 3.5.4.25 (GTP cyclohydrolase II).      Other names GTP Ring-Opening Enzyme; GTP Dihydrolase; GTP 8-Formylhydrolase; Synthetase, 7,8-Dihydroneopterintriphosphate; Ring-Opening Enzyme, GTP; GTP Ring Opening Enzyme; GTP 8 Formylhydrolase; Dihydrolase, GTP; Cyclohydrolase, GTP; Cyclohydrolase II, GTP; Cyclohydrolase I, GTP; 8-Formylhydrolase, GTP; 7,8 Dihydroneopterintriphosphate Synthetase; GTP Cyclohydrolase II; GTP Cyclohydrolase I; 7,8-Dihydroneopterintriphosphate Synthetase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Gchfr protein, rat  0   *Proteins GTP Cyclohydrolase.
RibBA protein, Helicobacter pylori  EC 3.5.4.25   *Bacterial Proteins *GTP Cyclohydrolase. J Bacteriol 1998 Mar;180(6):1473-9
GCHFR protein, human  0   *Intracellular Signaling Peptides and Proteins GTP Cyclohydrolase/antagonists & inhibitors. J Biol Chem 1996 Aug 16;271(33):19743-51
8-aminoguanosine triphosphate  101212-50-4 Guanosine 5'-(tetrahydrogen triphosphate), 8-amino  Guanosine Triphosphate/*analogs & derivatives GTP Cyclohydrolase/antagonists & inhibitors. Biochim Biophys Acta 1986;880(1):26
erythro-dihydrobiopterin triphosphate synthetase  EC 3.5.4.-   *GTP Cyclohydrolase. Biochem Biophys Res Commun 83(2):593;1978
2,4-diaminohypoxanthine  56-06-4   *Hypoxanthines GTP Cyclohydrolase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Neurochem Res 3(1):69;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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