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Harringtonines

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Definition: Tetracyclic spiro-BENZAZEPINES isolated from the seeds of CEPHALOTAXUS. They are esters of the alkaloid cephalotaxine and may be effective as antineoplastic agents.     
Pharmacological Action Antineoplastic Agents, Phytogenic 		Other names Cephalotaxus Alkaloids; Cephalotaxine Alkaloids; Alkaloids, Cephalotaxus; Alkaloids, Cephalotaxine
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cephalezomine H  0   *Harringtonines. J Org Chem. 2009 Oct 2;74(19):7592-4
HAD protocol  0   *Cytarabine *Daunorubicin *Harringtonines Antineoplastic Combined Chemotherapy Protocols. Am J Hematol 2009 Jul;84(7):422-7
2'-hydroxy-2'-(alpha-acetic acid)-6'-hydroxy-6'-methylheptanoyl cephalotaxine  0   *Harringtonines. J Exp Ther Oncol. 2003 Jan-Feb;3(1):47-52
HH07A  0   *Harringtonines. Yao Hsueh Hsueh Pao 1995;30(1):12-6
HATP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Doxorubicin Harringtonines Prednisone Thioguanine. Chung Hua Nei Ko Tsa Chih 1993 Jul;32(7):470-2
HAT regimen  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Harringtonines Thioguanine. Chung Hua Nei Ko Tsa Chih 1990;29(1):22
harringtonine  62624-24-2   *Harringtonines. Arch Immunol Ther Exp (Warsz) 1989;37(1-2):69
HVF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Harringtonines Vincristine. Chung Hua Wai Ko Tsa Chih 1988;26(11):648
GHVF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Harringtonines Phosphoramide Mustards Vincristine. Chung Hua Wai Ko Tsa Chih 1988;26(11):648
homoharringtonamide  119767-03-2 Cephalotaxine, 8-oxo-, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methypentyl)butanedioate (ester), (3(R))  *Harringtonines Drugs, Chinese Herbal. Yao Hsueh Hsueh Pao 1988;23(5):351
HOAAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Doxorubicin Harringtonines Prednisone Vincristine. Chung Hua Nei Ko Tsa Chih 1988;27(5):300
HOAGP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Harringtonines Prednisone Thioguanine Vincristine. Chung Hua I Hsueh Tsa Chih 1985;65(10):590
HOAP protocol  0   *Antineoplastic Combined Chemotherapy Protocols Cytarabine Harringtonines Prednisone Vincristine. Chung Hua I Hsueh Tsa Chih 1985;65(10):590
deoxyharringtonine  36804-95-2   *Harringtonines. Int J Cell Cloning 1984;2(5):327
hainanolidol  73213-63-5 Harringtonolide, 5,15-deepoxy-15-hydroxy-, (15R)  *Harringtonines. Chung Kuo Yao Li Hsueh Pao 1982;17(3):237
hainanensine  79233-02-6 1H-Cyclopenta(jk)(1,3)dioxolo(4,5-h)pyrrolo(2,1-b)(3)benzazepin-1-one, 2,7,8,10,11,12-hexahydro-2-hydroxy-2-methyl  *Harringtonines. Yao Hsueh Hsueh Pao 1981;16(1):24
hainanolide  64761-48-4 Harringtonolide  *Harringtonines. Acta Pharm Sin 14(1):39;1979
11-hydroxycephalotaxine  49686-55-7 Cephalotaxine, 11-hydroxy-, (11alpha)  *Harringtonines. J Org Chem 39(5):676;1974
drupacine  49686-57-9   *Harringtonines. J Org Chem 39(5):676;1974
isoharringtonine  26833-86-3 4-methylcephalotaxine 2,3-dihydroxy-2-(3-methylbutyl)butanedioate ester  *Harringtonines. J Pharm Sci 61(8):1227;1972
homoharringtonine  26833-87-4   *Harringtonines Leukemia, Myelogenous, Chronic, BCR-ABL Positive Apoptosis.
Pharma Action Antineoplastic Agents, Phytogenic ; Angiogenesis Inhibitors 		Chin Med J (Eng)92(3):175;1979; J Pharm Sci 61(8):1227;1972
cephalotaxine  24316-19-6   *Harringtonines. J Org Chem 41(3):551;1976; J Pharm Sci 61(8):1227;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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