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Hexokinase

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Definition: An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.      Other names Hexokinase II; Hexokinase D; Hexokinase A
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-bromo-2-oxopropionic acid  0   *Propionic Acids Hexokinase/antagonists & inhibitors. Electrophoresis 2009 Apr;30(8):1349-54
HK1 protein, mouse  EC 2.7.1.1   *Hexokinase. Proc Natl Acad Sci U S A 1992 Jan 1;89(1):202-6
hexokinase 2, Arabidopsis  EC 2.7.1.1   *Hexokinase *Arabidopsis Proteins. Plant Cell 2006 Sep;18(9):2341-55
HXK2 protein, S cerevisiae  EC 2.7.1.1   *Hexokinase *Saccharomyces cerevisiae Proteins.
ATHXK1 protein, Arabidopsis  EC 2.7.1.1.   *Hexokinase *Arabidopsis Proteins. Science 2003 Apr 11;300(5617):332-6
HK1 protein, human  EC 2.7.1.1   *Hexokinase. Blood 2003 Jan 1;101(1):345-7
XPRF protein, Emericella nidulans  EC 2.7.1.1   *Fungal Proteins *Hexokinase. Genetics 2000 Dec;156(4):1559-71
hexokinase Melzo  EC 2.7.1.-   *Hexokinase. Blood 1995;21(1):2-8
trehalose-6-phosphate  4484-88-2   *Sugar Phosphates Trehalose/*analogs & derivatives Hexokinase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		FEBS Lett 1993 Aug 23;329(1-2):51-4
Procion Reactive Red 4  16480-43-6   *Triazines Hexokinase/antagonists & inhibitors. Aust Dent J 1991;36(2):87
2-isobutyl-3-oxo-4-chloro-2-butylcarbonate  81652-49-5 Carbonic acid, 3-chloro-1-methyl-2-oxopropyl 2-methylpropyl ester  *Lactates Hexokinase/antagonists & inhibitors Protein Kinase Inhibitors/antagonists & inhibitors. Biochemistry 1982;21(12):2984
2-deoxy-2-amino-N-(5-dimethylamino-1-naphthalenesulfonyl)glucose  70393-78-1 D-Glucose, 2-deoxy-2-(((5-(dimethylamino)-1-naphthalenyl)sulfonyl)amino)  Glucosamine/*analogs & derivatives Hexokinase/antagonists & inhibitors. Prep Biochem 9(1):85;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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