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Isocitrate Dehydrogenase

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Definition: An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.      Other names NAD Isocitrate Dehydrogenase; Isocitrate Dehydrogenase, NAD; Isocitrate Dehydrogenase I; Dehydrogenase, NAD Isocitrate; Dehydrogenase, Isocitrate; Isocitrate Dehydrogenase-I; Isocitrate Dehydrogenase (NAD+)
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
IDHKP protein, E coli  EC 1.1.1.41   *Isocitrate Dehydrogenase *Escherichia coli Proteins. Science. 2010 Mar 12;327(5971):1389-91
IDH1 protein, human  EC 1.1.1.42.   *Isocitrate Dehydrogenase. N Engl J Med. 2009 Sep 10;361(11); 1058-66
isocitrate dehydrogenase 2, human  EC 1.1.1.41   *Isocitrate Dehydrogenase. N Engl J Med. 2009 Feb 19;360(8):765-73
At4g35650 protein, Arabidopsis  EC 1.1.1.41   *Isocitrate Dehydrogenase *Arabidopsis Proteins. Plant Cell Physiol 2006 May;47(5):634-43
isocitrate dehydrogenase II, Mycobacterium bovis  EC 1.1.1.-   *Bacterial Proteins *Isocitrate Dehydrogenase Bacterial Proteins. Clin Diagn Lab Immunol 2002 Jul;9(4):846-51
8-(4-bromo-2,3-dioxobutylthio)NAD  154591-46-5 Adenosine 5'-(trihydrogen (diphosphate)), 8-((4-bromo-2,3-dioxobutyl)thio)-, P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt  NAD/*analogs & derivatives Isocitrate Dehydrogenase. Arch Biochem Biophys 1994 Feb 1;308(2):357-66
isocitrate dehydrogenase (NADP+)  EC 1.1.1.42   *Isocitrate Dehydrogenase. Z Allg Mikrobiol 1983;23(6):403

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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