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Lactosylceramides

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Definition: Glycosphingolipids which contain as their polar head group a lactose moiety bound in glycosidic linkage to the hydroxyl group of ceramide. Their accumulation in tissue, due to a defect in lactosylceramide beta-galactosidase, is the cause of lactosylceramidosis.  /biosyn /physiol permitted    Other names Lactosyl Ceramides; Ceramides, Lactosyl
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
lactosyl-beta1-1-N-octanoylsphingosine  0   *Lactosylceramides. Curr Protoc Cell Biol 2007 Jun;Chapter 24:unit 24.1
BODIPY-LacCer  0   *Boron Compounds *Lactosylceramides. Curr Protoc Cell Biol 2007 Jun;Chapter 24:unit 24.1
N-acetylglucosaminyl-beta-1-3-galactosyl-1-4-(N-acetylglucosaminyl)-1-3-galactosyl-1-4-glucosyl-1-ceramide  97666-64-3   *Lactosylceramides. Biochem Biophys Res Comm 1993 Dec 30;197(3):1025-33
lactoisooctaosylceramide  104042-02-6   *Lactosylceramides. Mol Immuol 1986;23(7):747
lacto-N-neohexaosylceramide  86993-34-2   *Lactosylceramides. Biochim Biophys Acta 1986;876(2):363
trisialosyllactosylceramide  73904-48-0   *Gangliosides *Lactosylceramides. FEBS Lett 1986;196(2):259
N-acetylneuraminosyl lacto-N-noroctaosyl ceramide  77700-05-1 Paragloboside, O- (N-acetyl-alpha-neuraminosyl)-(2-3)-O-beta-D-galactopyranosyl-(1-4)-O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-4)-O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-3D)  *Lactosylceramides. J Biochem (Tokyo) 1981;89(4):1253
lactotriaosylceramide  73467-80-8 Ceramide, 1-O-(O-2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl-(1-3)-O-beta-D-galactopyranosyl-(1-4)-beta-D-glucopyranosyl)  *Lactosylceramides. J Lipid Res 1980;21(4):473
CDw17 antigen  4682-48-8 Ceramide, 1-O-(4-O-beta-D-galactopyranosyl-beta-glucopyranosyl)  *Lactosylceramides *Antigens, CD. Chem Phys Lipids 13(4):352;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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