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Leukocidins

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Definition: Pore forming proteins originally discovered for toxic activity to LEUKOCYTES. They are EXOTOXINS produced by some pathogenic STAPHYLOCOCCUS and STREPTOCOCCUS that destroy leukocytes by lysis of the cytoplasmic granules and are partially responsible for the pathogenicity of the organisms.  /antag permitted but consider also ANTITOXINS   
Pharmacological Action Cytotoxins 		Other names Proteins, Leukocidin; Leukocidin Proteins; Leukocidin; Leucocidin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Pseudomonas aeruginosa Cytotoxins  0   *Leukocidins.
leukocidin S-component protein, Staphylococcus  0   *Bacterial Proteins *Leukocidins Staphylococcus aureus. FEBS Lett 1997 Sep 22;415(1):96-100
LukM protein, Staphylococcus aureus  0   *Bacterial Proteins Leukocidins. FEBS Lett 1995 Jan 9;357(3):260-4
Panton-Valentine leukocidin  0   *Bacterial Toxins *Exotoxins *Leukocidins Staphylococcus aureus. Dermatology 1992;185(3):175-80
LukF protein, Staphylococcus aureus  147096-70-6   *Bacterial Proteins *Leukocidins Staphylococcus aureus. Biochem Biophys Res Commun 1992 Apr 30;184(2):640-6

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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