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Lewis Blood-Group System

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Definition: A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.  IM; coord with disease /blood, not /immunol nor /genet; TN 230   
Examples Antigens, CD15; CA-19-9 Antigen 		Other names Lewis System; System, Lewis Blood-Group; System, Lewis; Lewis Blood Group System; Le Antigen; Blood-Group System, Lewis; Antigens, Le; Antigen, Le; Le(a) Blood Group System; Le Antigens
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-aminopropyl fucopyranosyl-1-2-galactopyranosyl-1-3-(fucopyranosyl-1-4)-2-acetamido-2-deoxyglucopyranosyl-1-3-galactopyranosyl-1-4-glucopyranoside  0   *Oligosaccharides Lewis Blood-Group System. Glycoconj J 2004;21(5):251-6
N-deacetylsialyl Lewis X ganglioside  0   *Gangliosides Lewis Blood-Group System. Carbohydr Res. 2002 Nov 19;337(21-23):2111-7
mucin-type sialyl Lewis x epitope  0   *Oligosaccharides Lewis Blood-Group System. Glycoconj J 1999 Sep;16(9):487-97
sialyl-trimeric-Lewis X  0   *Antigens, CD15 Lewis Blood-Group System. Chemistry 2000 Apr 3;6(7):1243-51
galactopyranosyl-1-3-galactopyranosyl-1-3(4)-N-acetylglucosamine  0   *Oligosaccharides Lewis Blood-Group System. Eur J Biochem 2000 Jan;267(2):305-20
sulfo-Lewis(a)  0   *Oligosaccharides Lewis Blood-Group System. Biochem Biophys Res Commun 1998 Dec 18;253(2):374-81
cylexin  0   *Oligosaccharides Lewis Blood-Group System. Transplant Proc 1998 Nov;30(7A):2927-8
sulfo Lewis C  0   *Oligosaccharides Lewis Blood-Group System. Crit Care Med 1998 Jul;26(7):1238-43
CY 1747  0   *Oligosaccharides Lewis Blood-Group System. J Trauma 1997 Aug;43(2):313-8
LX 0104  0   *Oligosaccharides Lewis Blood-Group System Antigens, CD15. Int Arch Allergy Immunol 1996;111(Suppl 1):32-6
sulfated Le(a) pentaosylceramide  0   *Glycosphingolipids Lewis Blood-Group System. Carbohydr Res 1995 Apr 30;270(2):C9-13
sialyl Lewis(x) ganglioside  0   *Gangliosides Lewis Blood-Group System. Biosci Biotechnol Biochem 1995 Jun;59(6):1091-4
Lewis Y antigen  0   *Lewis Blood-Group System. Biol Reprod 1995 Apr;52(4):903-12
di-sialyl Le(a)  0   *Gangliosides Lewis Blood-Group System. Cancer Res 1995 May 1;55(9):1869-74
3-sulfo-Le(x) pentaosylceramide  162635-35-0   *Glycosphingolipids Lewis Blood-Group System. Carbohydr Res 1994 Oct 17;263(2):C1-6
2,3-disulfo-Le(x) pentaosylceramide  162635-34-9   *Glycosphingolipids Lewis Blood-Group System. Carbohydr Res 1994 Oct 17;263(2):C1-6
5-acetylneuraminyl-(2-3)-galactosyl-(1-4)-(fucopyranosyl-(1-3))-N-acetylglucosamine  0   *Oligosaccharides Lewis Blood-Group System Antigens, CD15. Carbohydr Res 1993 Dec 16;250(1):145-60
MIA antigen, human  0   *Antigens, Tumor-Associated, Carbohydrate Lewis Blood-Group System. N Engl J Med 1992 Jul 2;327(1):14-8
sialyl Le(a) ganglioside  91847-18-6   *Gangliosides Lewis Blood-Group System Tumor Markers, Biological Antigens, Tumor-Associated, Carbohydrate. Int J Cancer 1990;45(6):1204

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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