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Lipid Peroxides

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Definition: Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.      Other names Peroxides, Lipid; Hydroperoxides, Fatty Acid; Hydroperoxide, Lipid; Acid Hydroperoxides, Fatty; Lipoperoxides; Lipid Hydroperoxide; Fatty Acid Hydroperoxides
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
9-hydroperoxy-10,12-octadecadienoic acid  0   *Linoleic Acids *Lipid Peroxides. Biosci Biotechnol Biochem 2005 Sep;69(9):1661-8
3-(4'-methyl-1'-naphthyl)propionic acid 1',4'-endoperoxide  0   *Lipid Peroxides *Propionates. FEBS Lett 1998 Jul 31;432(1-2):9-12
9-hydroperoxy-10,12,15-octadecatrienoic acid  111004-08-1   *Lipid Peroxides. Biochem Biophys Res Commun 1989;162(3):1357
13-hydroperoxy-9,11,15-octadecatrienoic acid  28836-09-1   *Lipid Peroxides Linolenic Acids. Biochem Biophys Res Commun 1988;156(1):543
5,15-dihydroperoxyeicosatetraenoic acid  76964-60-8   *Lipid Peroxides *Leukotrienes. Biochem Biophys Res Commun 1987;149(3):1063
14,15-dihydroperoxyeicosatetraenoic acid  0   *Lipid Peroxides *Leukotrienes. Adv Prostaglandin Thromboxane Leukotriene Res 1987;17A:75
8,15-diHPETE  62054-47-1   *Lipid Peroxides *Leukotrienes. Adv Prostaglandin Thromboxane Leukotriene Res 1987;17B:1103
cholesterol 7-hydroperoxide  2846-29-9   Cholesterol/*analogs & derivatives Lipid Peroxides.
Pharma Action Mutagens 		J Steroid Biochem 1984;20(4A):917
13-hydroperoxy-9,11-octadecadienoic acid  23017-93-8   *Linoleic Acids *Lipid Peroxides. Biochim Biophys Acta 1983;752(2):191
methyl oleate hydroperoxide  25155-13-9   *Lipid Peroxides. Ecotoxicol Environ Safety 1983;7(2):242
docosahexaenoic acid hydroperoxide  83771-36-2   *Docosahexaenoic Acids *Lipid Peroxides. Exp Eye Res 1982;35(2):157
lauroyl peroxide  105-74-8   *Lipid Peroxides. J Invest Dermatol 1982;79(1):30
13-hydroperoxylinolenic acid  19356-22-0   *Linolenic Acids *Lipid Peroxides. Lipids 1980;15(6):468
15-hydroperoxy-5,8,11,13-eicosatetraenoic acid  67675-14-3 5,8,11,13-eicosatetraenoic acid, 15-hydroperoxy  *Lipid Peroxides *Leukotrienes.
Pharma Action Vasoconstrictor Agents ; Lipoxygenase Inhibitors 		Adv Prostaglandin Thromboxane Res 1:139;1976; Adv Prostaglandin Thromboxane Res 1980;6:149; Arch Int Pharmacodyn 1979;242(2):285; Arch Int Pharmacodyn 220:297;1976; Experientia 30(2):172;1974; Nature 273(5665):765;1978; Nippon Ronen Igakkai Zasshi 1980;17(1):70; Prostaglandins 1979;18(6):909
hydroperoxidobutyloleate  0   *Lipid Peroxides. Nahrung 20(1):1;1976
methyl linoleate hydroperoxide  27323-65-5   *Lipid Peroxides. Arch Environ Health 28(2):82;1974; Arch Pathol Lab Med 100(3):154;1976
linoleic acid hydroperoxide  25657-09-4 hydroperoxy-9,12-octadecadienoic acid  *Linoleic Acids *Lipid Peroxides. Arch Biochem Biophys 193(1):51;1979; Biochem Biophys Res Commun 89(2):464;1979; Biochim Biophys Acta 1979;575(3):479; J Biochem (Tokyo):1979;86(4):1041; J Nutr Sci Vitaminol 22(3):267;1976; Jpn J Pharmacol 1979;29(2):179; Lipids 12(3):324;1977; Lipids 1980;15(1):1; Lipids 1980;15(1):45; Radiobiologiia 16(3):455;1976; Science 182(119):1364;1973
cholesterol hydroperoxide  55529-60-7 3 beta-hydroxy-5 alpha-hydroperoxy-delta-6- cholestene  Cholesterol/*analogs & derivatives Lipid Peroxides.
Pharma Action Mutagens 		BBA 487(2):395;1977; Science 179(078):1131;1973

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