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Neuraminidase

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Definition: An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)      Other names Sialidase; Sialidase, Oligosaccharide; N Acylneuraminate Glycohydrolases; Glycohydrolases, N-Acylneuraminate; Exo alpha Sialidase; Oligosaccharide Sialidase; N-Acylneuraminate Glycohydrolases; Exo-alpha-Sialidase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-acetyl-2,3-dehydro-2-deoxyneuraminic acid  0   N-Acetylneuraminic Acid/*analogs & derivatives Neuraminidase/antagonists & inhibitors. Eur J Neurosci 2010 Dec;32(11):1889-96
HR 1039  0   *Disaccharides *Triterpenes Neuraminidase/antagonists & inhibitors. Biophys Chem 2010 Mar;147(1-2):74-80
R 125489  0   Zanamivir/*analogs & derivatives Neuraminidase/antagonists & inhibitors. Antimicrob Agents Chemother 2009 Jan;53(1):186-92
NA protein, influenza B virus  EC 3.2.1.18   *Neuraminidase *Viral Proteins. Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):485-99
Neu2 protein, rat  EC 3.2.1.18   *Neuraminidase. Biochem Biophys Res Commun 2008 May 30;370(2):376-81
Neu2 protein, mouse  EC 3.2.1.18   *Neuraminidase. FEBS J 2006 Aug;273(16):3709-21
Neu3 protein, mouse  EC 3.2.1.18   *Neuraminidase Membrane Proteins. J Biol Chem 2000 Mar 17;275(11):8007-15
5-acetamido-2-(4-N-5-dimethylaminonaphthalene-1-sulfonyl-2-difluoromethylphenyl)-3,5-dideoxygalacto-2-nonulopyranosonic acid  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. Biochemistry 2005 Sep 6;44(35):11669-75
2,2'-(benzene-1,4-diylbis((oxomethanediyl)imino-3,1-propanediylimino(oxomethanediyl)oxy)(2,3-dihydroxy-1,1-propanediyl)))bis(3-(acetylamino)-4-((amino(imino)methyl)amino)-3,4-dihydro-2H-pyran-6-carboxylic acid  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):2964-71
4,4'-bis(4'-(((((1-(3-(acetylamino)-4-((amino(imino)methyl)amino)-6-carboxy-3,4-dihydro-2H-pyran-2-yl)-2,3-dihydroxypropyl)oxy)carbonyl)amino)methyl))biphenyl  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):2964-71
NanH sialidase, Pasteurella multocida  EC 3.2.1.18   *Neuraminidase. Clin Diagn Lab Immunol 2004 Sep;11(5):825-34
BANA 207  0   *Aminobenzoic Acids *Pyrrolidinones Neuraminidase/antagonists & inhibitors. Acta Crystallogr D Biol Crystallogr 2004 Jun;60(Pt 6):1017-23
ASP-2 protein, Trypanosoma cruzi  EC 3.2.1.18   *Neuraminidase. Mol Biochem Parasitol 1997 Sep;88(1-2):137-49
NEU4 protein, human  EC 3.2.1.18   *Neuraminidase. J Biol Chem 2004 Aug 27;279(35):37021-9
NA protein, influenza A virus  EC 3.2.1.18   *Neuraminidase *Viral Proteins. Virus Res 2004 Mar 15;100(2):153-7
NEU1 protein, human  EC 3.2.1.18   *Neuraminidase.
Neu4 protein, mouse  EC 3.2.1.18   *Neuraminidase. Gene 2003 Dec 4;321:155-61
Neu3 protein, human  EC 3.2.1.18   *Neuraminidase Neoplasm Proteins. Proc Natl Acad Sci U S A 2002 Aug 6;99(16):10718-23
A 315675  0   *Pyrrolidines Neuraminidase/antagonists & inhibitors. J Virol 2002 Jun;76(11):5380-6
nobiloside  0   *Sterols *Trisaccharides Neuraminidase/antagonists & inhibitors. J Nat Prod 2002 Mar;65(3):411-3
NanH protein, Arcanobacterium pyogenes  EC 3.2.1.18   *Bacterial Proteins *Neuraminidase. Infect Immun 2001 Jul;69(7):4430-7
A 192558  0   *Pyrrolidines Neuraminidase/antagonists & inhibitors. J Med Chem 2001 Apr 12;44(8):1192-201
peramivir  0 3-(1-acetamido-2-ethyl-butyl)-4-guanidino-2-hydroxy-cyclopentane-1-carboxylic acid  *Cyclopentanes *Guanidines Neuraminidase/antagonists & inhibitors. J Med Chem 2000 Sep 21;43(19):3482-6
NEU2 protein, human  EC 3.2.1.18   *Neuraminidase. Genomics 1999 Apr 1;57(1):137-43
4-acetylamino-3-hydroxy-5-n-propoxybicyclo(2.2.2)octane-1-carboxylic acid  0   *Bicyclo Compounds *Carboxylic Acids Neuraminidase/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Feb 8;9(3):611-4
BCX 140  0   *Benzoates Neuraminidase/antagonists & inhibitors. Antimicrob Agents Chemother 1998 Apr;42(4):801-7
5-(acetylamino)-4-amino-6-(phenethylpropylcarbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid  0   *Acetamides *Pyrans Neuraminidase/antagonists & inhibitors. J Med Chem 1998 Mar 12;41(6):798-807
Neu1 protein, mouse  EC 3.2.1.18   *Neuraminidase. Glycobiology 1997 Oct;7(7):975-86
4-difluoromethyl-2-methoxyphenyl-ketoside-N-acetylneuraminic acid  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. Arch Virol 1997;142(7):1365-80
2-difluoromethylphenyl-ketoside-N-acetylneuraminic acid  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. Arch Virol 1997;142(7):1365-80
amastigote surface protein-1  EC 3.2.1.-   *Membrane Proteins *Neuraminidase Protozoan Proteins. Mol Biochem Parasitol 1997 May;86(1):1-11
6-acetamido-6,8-dideoxy-erythro-galacto-octopyranosyl-1-oxyacetic acid  0   *Acetic Acids *Amino Sugars Neuraminidase/antagonists & inhibitors. Arch Pharm (Weinheim) 1997 Jan-Feb;330(1-2):17-20
3,5-diguanidino-4-(N-acetylamino)benzoic acid  0   *Guanidines *Hydroxybenzoic Acids Neuraminidase/antagonists & inhibitors. J Mol Biol 1997 Apr 4;267(3):584-94
sialidase L  EC 3.2.1.-   *Neuraminidase. J Biol Chem 1996 Aug 9;271(32):19219-24
(4-acetamido-2,4-dideoxyglycerogalactooctopyranosyl)phosphonic acid  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. J Mol Biol 1996 Jun 7;259(2):264-80
4-(acetylamino)-5-guanidino-3-hydroxybenzoic acid  0   *Guanidines *Hydroxybenzoic Acids Neuraminidase/antagonists & inhibitors. Proteins 1995 Oct;23(2):264-77
BANA 105  0   *Nitrobenzoates Neuraminidase/antagonists & inhibitors. Biochemistry 1995 Mar 14;34(10):3144-51
4-(acetylamino)-3-hydroxy-5-aminobenzoic acid  0   *Aminobenzoic Acids Neuraminidase/antagonists & inhibitors. Biochemistry 1995 Mar 14;34(10):3144-51
4-(acetylamino)-3-aminobenzoic acid  0   *Aminobenzoic Acids Neuraminidase/antagonists & inhibitors. Biochemistry 1995 Mar 14;34(10):3144-51
4-deoxysiastatin B  148112-84-9   *Piperidines Neuraminidase/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Oct;45(10):1662-8
3,4-didehydro-4-deoxysiastatin B  142779-94-0   *Piperidines Neuraminidase/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Oct;45(10):1662-8
trans-sialidase  EC 3.2.1.-   *Glycoproteins *Neuraminidase Antigens, Protozoan. Cell 1991;65(7):1117; Mol Biochem Parasitol 1991 Aug;47(2):247-50
(phenyl 5-acetamido-3,5-dideoxy-2-selenononulopyranosid)onic acid  131569-90-9   *Sialic Acids *Organoselenium Compounds Neuraminidase/antagonists & inhibitors. Carbohydr Res 1990;208:251
2,3-dehydroneuraminic acid  41976-42-5   *Neuraminic Acids Neuraminidase/antagonists & inhibitors. Biochem Biophys Res Commun 1985;129(3):739
2-deoxy-2,3-dehydro-N-acetylneuraminic acid  24967-27-9 D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-2,6-anhydro-3,5-dideoxy  N-Acetylneuraminic Acid/*analogs & derivatives Neuraminidase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Eur J Biochem 1982;126(3):543
GM3 ganglioside sialidase  EC 3.2.1.18   *Neuraminidase. No To Shinkei 1982;34(7):666
endo-N-acetylneuraminidase  EC 3.2.1.-   *Neuraminidase. J Virol 1982;43(2):697
siastatin  56573-74-1 Siastatin  *Piperidines Neuraminidase/antagonists & inhibitors Stereoisomerism. J Antibiot (Tokyo) 27(12):963;1974

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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