encyclopedia of medical concepts
ψ 

Neuraminidase

More information in Books or onNLM PubMed
Definition: An enzyme that catalyzes the hydrolysis of alpha-2,3, alpha-2,6-, and alpha-2,8-glycosidic linkages (at a decreasing rate, respectively) of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid, and synthetic substrate. (From Enzyme Nomenclature, 1992)      Other names Sialidase; Sialidase, Oligosaccharide; N Acylneuraminate Glycohydrolases; Glycohydrolases, N-Acylneuraminate; Exo alpha Sialidase; Oligosaccharide Sialidase; N-Acylneuraminate Glycohydrolases; Exo-alpha-Sialidase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-acetyl-2,3-dehydro-2-deoxyneuraminic acid  0   N-Acetylneuraminic Acid/*analogs & derivatives Neuraminidase/antagonists & inhibitors. Eur J Neurosci 2010 Dec;32(11):1889-96
HR 1039  0   *Disaccharides *Triterpenes Neuraminidase/antagonists & inhibitors. Biophys Chem 2010 Mar;147(1-2):74-80
R 125489  0   Zanamivir/*analogs & derivatives Neuraminidase/antagonists & inhibitors. Antimicrob Agents Chemother 2009 Jan;53(1):186-92
NA protein, influenza B virus  EC 3.2.1.18   *Neuraminidase *Viral Proteins. Acta Crystallogr D Biol Crystallogr. 2009 May;65(Pt 5):485-99
Neu2 protein, rat  EC 3.2.1.18   *Neuraminidase. Biochem Biophys Res Commun 2008 May 30;370(2):376-81
Neu2 protein, mouse  EC 3.2.1.18   *Neuraminidase. FEBS J 2006 Aug;273(16):3709-21
Neu3 protein, mouse  EC 3.2.1.18   *Neuraminidase Membrane Proteins. J Biol Chem 2000 Mar 17;275(11):8007-15
5-acetamido-2-(4-N-5-dimethylaminonaphthalene-1-sulfonyl-2-difluoromethylphenyl)-3,5-dideoxygalacto-2-nonulopyranosonic acid  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. Biochemistry 2005 Sep 6;44(35):11669-75
2,2'-(benzene-1,4-diylbis((oxomethanediyl)imino-3,1-propanediylimino(oxomethanediyl)oxy)(2,3-dihydroxy-1,1-propanediyl)))bis(3-(acetylamino)-4-((amino(imino)methyl)amino)-3,4-dihydro-2H-pyran-6-carboxylic acid  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):2964-71
4,4'-bis(4'-(((((1-(3-(acetylamino)-4-((amino(imino)methyl)amino)-6-carboxy-3,4-dihydro-2H-pyran-2-yl)-2,3-dihydroxypropyl)oxy)carbonyl)amino)methyl))biphenyl  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):2964-71
NanH sialidase, Pasteurella multocida  EC 3.2.1.18   *Neuraminidase. Clin Diagn Lab Immunol 2004 Sep;11(5):825-34
BANA 207  0   *Aminobenzoic Acids *Pyrrolidinones Neuraminidase/antagonists & inhibitors. Acta Crystallogr D Biol Crystallogr 2004 Jun;60(Pt 6):1017-23
ASP-2 protein, Trypanosoma cruzi  EC 3.2.1.18   *Neuraminidase. Mol Biochem Parasitol 1997 Sep;88(1-2):137-49
NEU4 protein, human  EC 3.2.1.18   *Neuraminidase. J Biol Chem 2004 Aug 27;279(35):37021-9
NA protein, influenza A virus  EC 3.2.1.18   *Neuraminidase *Viral Proteins. Virus Res 2004 Mar 15;100(2):153-7
NEU1 protein, human  EC 3.2.1.18   *Neuraminidase.
Neu4 protein, mouse  EC 3.2.1.18   *Neuraminidase. Gene 2003 Dec 4;321:155-61
Neu3 protein, human  EC 3.2.1.18   *Neuraminidase Neoplasm Proteins. Proc Natl Acad Sci U S A 2002 Aug 6;99(16):10718-23
A 315675  0   *Pyrrolidines Neuraminidase/antagonists & inhibitors. J Virol 2002 Jun;76(11):5380-6
nobiloside  0   *Sterols *Trisaccharides Neuraminidase/antagonists & inhibitors. J Nat Prod 2002 Mar;65(3):411-3
NanH protein, Arcanobacterium pyogenes  EC 3.2.1.18   *Bacterial Proteins *Neuraminidase. Infect Immun 2001 Jul;69(7):4430-7
A 192558  0   *Pyrrolidines Neuraminidase/antagonists & inhibitors. J Med Chem 2001 Apr 12;44(8):1192-201
peramivir  0 3-(1-acetamido-2-ethyl-butyl)-4-guanidino-2-hydroxy-cyclopentane-1-carboxylic acid  *Cyclopentanes *Guanidines Neuraminidase/antagonists & inhibitors. J Med Chem 2000 Sep 21;43(19):3482-6
NEU2 protein, human  EC 3.2.1.18   *Neuraminidase. Genomics 1999 Apr 1;57(1):137-43
4-acetylamino-3-hydroxy-5-n-propoxybicyclo(2.2.2)octane-1-carboxylic acid  0   *Bicyclo Compounds *Carboxylic Acids Neuraminidase/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Feb 8;9(3):611-4
BCX 140  0   *Benzoates Neuraminidase/antagonists & inhibitors. Antimicrob Agents Chemother 1998 Apr;42(4):801-7
5-(acetylamino)-4-amino-6-(phenethylpropylcarbamoyl)-5,6-dihydro-4H-pyran-2-carboxylic acid  0   *Acetamides *Pyrans Neuraminidase/antagonists & inhibitors. J Med Chem 1998 Mar 12;41(6):798-807
Neu1 protein, mouse  EC 3.2.1.18   *Neuraminidase. Glycobiology 1997 Oct;7(7):975-86
4-difluoromethyl-2-methoxyphenyl-ketoside-N-acetylneuraminic acid  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. Arch Virol 1997;142(7):1365-80
2-difluoromethylphenyl-ketoside-N-acetylneuraminic acid  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. Arch Virol 1997;142(7):1365-80
amastigote surface protein-1  EC 3.2.1.-   *Membrane Proteins *Neuraminidase Protozoan Proteins. Mol Biochem Parasitol 1997 May;86(1):1-11
6-acetamido-6,8-dideoxy-erythro-galacto-octopyranosyl-1-oxyacetic acid  0   *Acetic Acids *Amino Sugars Neuraminidase/antagonists & inhibitors. Arch Pharm (Weinheim) 1997 Jan-Feb;330(1-2):17-20
3,5-diguanidino-4-(N-acetylamino)benzoic acid  0   *Guanidines *Hydroxybenzoic Acids Neuraminidase/antagonists & inhibitors. J Mol Biol 1997 Apr 4;267(3):584-94
sialidase L  EC 3.2.1.-   *Neuraminidase. J Biol Chem 1996 Aug 9;271(32):19219-24
(4-acetamido-2,4-dideoxyglycerogalactooctopyranosyl)phosphonic acid  0   *Sialic Acids Neuraminidase/antagonists & inhibitors. J Mol Biol 1996 Jun 7;259(2):264-80
4-(acetylamino)-5-guanidino-3-hydroxybenzoic acid  0   *Guanidines *Hydroxybenzoic Acids Neuraminidase/antagonists & inhibitors. Proteins 1995 Oct;23(2):264-77
BANA 105  0   *Nitrobenzoates Neuraminidase/antagonists & inhibitors. Biochemistry 1995 Mar 14;34(10):3144-51
4-(acetylamino)-3-hydroxy-5-aminobenzoic acid  0   *Aminobenzoic Acids Neuraminidase/antagonists & inhibitors. Biochemistry 1995 Mar 14;34(10):3144-51
4-(acetylamino)-3-aminobenzoic acid  0   *Aminobenzoic Acids Neuraminidase/antagonists & inhibitors. Biochemistry 1995 Mar 14;34(10):3144-51
4-deoxysiastatin B  148112-84-9   *Piperidines Neuraminidase/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Oct;45(10):1662-8
3,4-didehydro-4-deoxysiastatin B  142779-94-0   *Piperidines Neuraminidase/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Oct;45(10):1662-8
trans-sialidase  EC 3.2.1.-   *Glycoproteins *Neuraminidase Antigens, Protozoan. Cell 1991;65(7):1117; Mol Biochem Parasitol 1991 Aug;47(2):247-50
(phenyl 5-acetamido-3,5-dideoxy-2-selenononulopyranosid)onic acid  131569-90-9   *Sialic Acids *Organoselenium Compounds Neuraminidase/antagonists & inhibitors. Carbohydr Res 1990;208:251
2,3-dehydroneuraminic acid  41976-42-5   *Neuraminic Acids Neuraminidase/antagonists & inhibitors. Biochem Biophys Res Commun 1985;129(3):739
2-deoxy-2,3-dehydro-N-acetylneuraminic acid  24967-27-9 D-glycero-D-galacto-Non-2-enonic acid, 5-(acetylamino)-2,6-anhydro-3,5-dideoxy  N-Acetylneuraminic Acid/*analogs & derivatives Neuraminidase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
Eur J Biochem 1982;126(3):543
GM3 ganglioside sialidase  EC 3.2.1.18   *Neuraminidase. No To Shinkei 1982;34(7):666
endo-N-acetylneuraminidase  EC 3.2.1.-   *Neuraminidase. J Virol 1982;43(2):697
siastatin  56573-74-1 Siastatin  *Piperidines Neuraminidase/antagonists & inhibitors Stereoisomerism. J Antibiot (Tokyo) 27(12):963;1974

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify.
We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy