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Orotate Phosphoribosyltransferase

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Definition: The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.  /defic: consider also OROTIC ACID /urine (IM) + PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS (IM)    Other names Orotidylic Acid Phosphorylase; Orotidine-5'-Phosphate Pyrophosphorylase; Pyrophosphorylase, Orotidine-5'-Phosphate; Phosphorylase, Orotidylic Acid; Phosphoribosyltransferase, Orotate; Phosphohydrolase, Orotidine-5'-Monophosphate; Orotidine 5' Phosphate Pyrophosphorylase; Orotidine 5' Monophosphate Phosphohydrolase; Orotidine-5'-Monophosphate Phosphohydrolase; OMPase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Oroticaciduria 1  0   *Purine-Pyrimidine Metabolism, Inborn Errors Orotate Phosphoribosyltransferase/deficiency Orotidine-5'-Phosphate Decarboxylase/deficiency.
uridine 5'-monophosphate synthase  74870-74-9 Synthase, uridylate  *Multienzyme Complexes *Orotate Phosphoribosyltransferase *Orotidine-5'-Phosphate Decarboxylase. Biochemistry 1980;19(20):4699

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