encyclopedia of medical concepts
ψ
Orotate Phosphoribosyltransferase
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Definition
: The enzyme catalyzing the formation of orotidine-5'-phosphoric acid (orotidylic acid) from orotic acid and 5-phosphoribosyl-1-pyrophosphate in the course of pyrimidine nucleotide biosynthesis. EC 2.4.2.10.
/defic: consider also OROTIC ACID /urine (IM) + PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS (IM)
Other names
Orotidylic Acid Phosphorylase; Orotidine-
5'-
Phosphate Pyrophosphorylase; Pyrophosphorylase, Orotidine-
5'-
Phosphate; Phosphorylase, Orotidylic Acid; Phosphoribosyltransferase, Orotate; Phosphohydrolase, Orotidine-
5'-
Monophosphate; Orotidine 5' Phosphate Pyrophosphorylase; Orotidine 5' Monophosphate Phosphohydrolase; Orotidine-
5'-
Monophosphate Phosphohydrolase; OMPase
Substance
CAS Registry & name
Categories
Source
Drugs
*
Oroticaciduria 1
0
*Purine-Pyrimidine Metabolism, Inborn Errors
Orotate Phosphoribosyltransferase/deficiency
Orotidine-5'-Phosphate Decarboxylase/deficiency.
uridine 5'-
monophosphate synthase
74870-74-9 Synthase, uridylate
*Multienzyme Complexes
*Orotate Phosphoribosyltransferase
*Orotidine-5'-Phosphate Decarboxylase.
Biochemistry 1980;19(20):4699