Orotidine-5'-Phosphate Decarboxylase (definition)

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ψ	Orotidine-5'-Phosphate Decarboxylase

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Definition: Orotidine-5'-phosphate carboxy-lyase. Catalyzes the decarboxylation of orotidylic acid to yield uridylic acid in the final step of the pyrimidine nucleotide biosynthesis pathway. EC 4.1.1.23.

/defic: consider also OROTIC ACID /urine (IM) + PURINE-PYRIMIDINE METABOLISM, INBORN ERRORS (IM); DF: OMP DECARBOXYLASE

Other names Orotidylate Decarboxylase; Orotidine Phosphate Carboxy-Lyase; Phosphate Carboxy-Lyase, Orotidine; Orotidine Phosphate Carboxy Lyase; Decarboxylase, Orotidylate; Decarboxylase, Orotidine-5-Phosphate; Decarboxylase, Orotidine-5'-Phosphate; Decarboxylase, OMP; Carboxy-Lyase, Orotidine Phosphate; Orotidine-5-Phosphate Decarboxylase; Orotidine 5' Phosphate Decarboxylase; Orotidine 5 Phosphate Decarboxylase; OMP Decarboxylase

Substance	CAS Registry & name	Categories	Source
Uridine monophosphate synthase deficiency	0	*Purine-Pyrimidine Metabolism, Inborn Errors Orotidine-5'-Phosphate Decarboxylase/deficiency.
Oroticaciduria 1	0	*Purine-Pyrimidine Metabolism, Inborn Errors Orotate Phosphoribosyltransferase/deficiency Orotidine-5'-Phosphate Decarboxylase/deficiency.
6-iodouridine 5'-monophosphate	0	Uridine Monophosphate/*analogs & derivatives Orotidine-5'-Phosphate Decarboxylase/antagonists & inhibitors.	J Med Chem 2007 Mar 8;50(5):915-21
N 10169	90914-47-9	*Ribonucleosides Orotidine-5'-Phosphate Decarboxylase/antagonists & inhibitors.	Antimicrob Agents Chemother 1987;31(10):1535
uridine 5'-monophosphate synthase	74870-74-9 Synthase, uridylate	Multienzyme Complexes Orotate Phosphoribosyltransferase *Orotidine-5'-Phosphate Decarboxylase.	Biochemistry 1980;19(20):4699
pyrazofurin	30868-30-5	Ribonucleosides Orotidine-5'-Phosphate Decarboxylase/antagonists & inhibitors. Pharma Action* Anti-Bacterial Agents ; Antibiotics, Antineoplastic ; Antimetabolites, Antineoplastic ; Antiviral Agents ; Enzyme Inhibitors	Adv Carbohydr Chem Biochem 33:113;1976; Adv Enzyme Regul 1978;17:15; Ann NY Acad Sci 255:544;1975; Biochem Biophys Res Commun 51(2):312;1973; Biochem Pharmacol 28(12):1977;1979; Biochem Pharmacol 28(7):1189;1979; Cancer 40(5) Suppl:2681;1977; Cancer 40(6):2806;1977; Cancer Res 36(10):3807;1976; Cancer Res 37:2043;1977; Cancer Res 38(12):4610;1978; Cancer Res 38(8):2458;1978; Cancer Res 38:682;1978; Cancer Res 39(8):3089;1979; Cancer Treat Rep 1979;63(11-12):1857; Cancer Treat Rep 1979;63(11-12):2047; Cancer Treat Rep 61(3):389;1977; Cancer Treat Rep 61(3):491;1977; Cancer Treat Rep 61(9):1733;1977; Cancer Treat Rep 62(10):1569;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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