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Phorbol Esters
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Definition
: Tumor-promoting compounds obtained from CROTON OIL (Croton tiglium). Some of these are used in cell biological experiments as activators of protein kinase C.
a group of tumor-promoting cpds; GEN or unspecified: prefer specifics; index here only for a specific phorbol ester not in MeSH; D25-26 qualif
Pharmacological Action
Carcinogens
Examples
Phorbol 12,13-Dibutyrate
;
Tetradecanoylphorbol Acetate
Other names
Esters, Phorbol; Diesters, Phorbol; Phorbol Diesters
Substance
CAS Registry & name
Categories
Source
Drugs
*
4beta-
deoxy-
16-
hydroxyphorbol-
16-
acetate
0
*Phorbol Esters.
Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1289-91
16-
hydroxyphorbol-
16-
acetate
0
*Phorbol Esters.
Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1289-91
12-
O-
methoxymethylphorbol-
13-
decanoate
0
*Phorbol Esters.
Antivir Chem Chemother. 2005;16(5):303-13
12-
O-
benzyloxymethylphorbol-
13-
decanoate
0
*Phorbol Esters.
Antivir Chem Chemother. 2005;16(5):303-13
deoxyphorbol 13-
tetradecanoate
0
*Phorbol Esters.
Eur J Pharmacol 1999 Sep 17;381(1):77-84
phorbol-
12-
myristate
20839-06-9
*Phorbol Esters.
Diabetes 1999 Feb;48(2):279-86
phorbol 12-
phenylacetate 13-
acetate 20-
homovanillate
175796-50-6
*Phorbol Esters
Ligands
Receptors, Drug.
Eur J Pharmacol 1996 Mar 28;299(1-3):221-8
12-
deoxyphorbol 13-
(3,5-
decadienoate)
0
*Phorbol Esters.
J Nat Prod 1995 May;58(5):769-72
phorbol 12,13-
dibenzoate 20-
homovanillylamide
0
*Phorbol Esters.
J Neurochem 1995 Jul;65(1):234-40
thymeleatoxin
94482-56-1
*Phorbol Esters.
FEBS Lett 1993 Mar 15;319(1-2):31-4
phorbol-
13-
acetate-
12-
N-
methyl-
N-
4-
(N,N'-
di(2-
hydroxyethyl)amino)-
7-
nitrobenz-
2-
oxa-
1,3-
diazole-
aminododecanoate
137034-69-6
*Oxadiazoles
*Phorbol Esters.
J Cell Biochem 1991 Jul;46(3):266-76
prostratin
60857-08-1
*Phorbol Esters.
Cancer Res 1991;51(19):5355
sapintoxin D
80998-07-8 Benzoic acid, 2-
(methylamino)-
, (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-
9a-
(acetyloxy)-
1a,1b,4,4a,5,7a,7b,8,9,9a-
decahydro-
4a,7b-
dihydroxy-
3-
(hydroxymethyl)-
1,1,6,8-
tetramethyl-
5-
oxo-
1H-
cyclopropa(3,4)benz(1,2-
e)azulen-
9-
yl ester
*Phorbol Esters.
Pigment Cell Res 1990;3(2):98
12-
deoxy-
16-
hydroxyphorbol-
4'-
(12',14'-
butadienyl)-
6'-
(16',18',20'-
nonatrienyl)-
bicyclo(3.1.0)hexane-
(13-
O)-
2'-
(carboxylate)-
(16-
O)-
3'-
(8'-
butenoic-
10')ate
117855-87-5
*Phorbol Esters.
Cancer Res 1988;48(20):5800
phorbol 12,13,20-
triacetate
19891-05-5
*Phorbol Esters.
Endocrinology 1987;121(4):1503
phorbol 13-
monoacetate
32752-29-7
*Phorbol Esters.
J Biol Chem 1986;261(29):13606
12-
deoxyphorbol-
13-
isobutyrate-
20-
acetate
25090-71-5
*Phorbol Esters.
Biochem Biophys Res Commun 1986;134(3):1245
12-
O-
(5-
azido-
2-
nitrobenzoylphorbol)-
13-
acetate
96657-96-4 Benzoic acid, 5-
azido-
2-
nitro-
, 9a-
(acetyloxy)-
1a,1b,4,4a,5,7a,7b,8,9,9a-
decahydro-
4a,7b-
dihydroxy-
3-
(hydroxymethyl)-
1,1,6,8-
tetramethyl-
5-
oxo-
1H-
cyclopropa(3,4)benz(1,2-
e)azulen-
9-
yl ester, (1aR-
(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9))
*Azides
*Phorbol Esters.
Cancer Lett 1985;26(1):97
milliamine I
91197-54-5
*Phorbol Esters.
Planta Med 1984;50(4):319
milliamine H
91197-53-4
*Phorbol Esters.
Planta Med 1984;50(4):319
phorbol 13,20-
diacetate
41621-85-6
*Phorbol Esters.
Biocem Biophys Res Commun 1984;123(2):703
12-
deoxyphorbol 13-
isobutyrate
25090-74-8
*Phorbol Esters.
Cancer Res 1983;43(10):4632
ostodin
85527-84-0 Undecadienoic acid, 9a-
(acetyloxy)-
1a,1b,2,4a,5,7a,7b,8,9,9a-
decahydro-
2-
hydroperoxy-
4a,7b-
dihydroxy-
3-
(hydroxymethyl)-
1,1,6,8-
tetramethyl-
5-
oxo-
1H-
cyclopropa(3,4)benz(1,2-
e)azulen-
9-
yl ester, (1aR-
(1aalpha,1bbeta,2beta,4abeta,7aalpha,7balpha,8alpha,9bet
*Phorbol Esters.
J Nat Prod 1983;46(1):123
12-
O-
undecadienoylphorbol-
13-
acetate
85527-86-2 Undecadienoic acid, 9a-
(acetyloxy)-
1a,1b,4,4a,5,7a,7b,8,9,9a-
decahydro-
4a,7b-
dihydroxy-
3-
(hydroxymethyl)-
1,1,6,8-
tetramethyl-
5-
oxo-
1H-
cyclopropa(3,4)benz(1,2-
e)azulen-
9-
yl ester, (1aR-
(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9beta,9aalpha))
*Phorbol Esters.
J Nat Prod 1983;46(1):123
12-
deoxyphorbol-
13-
(2,4,6-
decatrienate)
80154-52-5 2,4,6-
Decatrienoic acid, 1,1a,1b,4,4a,5,7a,7b,8,9-
decahydro-
4a,7b-
dihydroxy-
3-
(hydroxymethyl)-
1,1,6,8-
tetramethyl-
5-
oxo-
9aH-
cyclopropa(3,4)benz(1,2-
e)azulen-
9a-
yl ester, (1aR-
(1aalpha,1bbeta,4abeta,7aalpha,7balpha,8alpha,9aalpha))
*Phorbol Esters.
Carcinogenesis 1982;7:305
12-
deoxyphorbol-
13-
decanoate
70278-05-6
*Phorbol Esters.
Carcinogenesis 1982;7:305
phorbol-
12,13-
dipropionate
51821-33-1
*Phorbol Esters.
Carcinogenesis 1982;7:57
12-
O-
retinoylphorbol-
13-
acetate
80188-99-4 Retinoic acid, 9a-
(acetyloxy)-
1a,1b,4,4a,5,7a,7b,8,9,9a-
decahydro-
4a,7b-
dihydroxy-