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Pro-Opiomelanocortin

More information in Books or onNLM PubMed
Definition: A 30-kDa protein synthesized primarily in the ANTERIOR PITUITARY GLAND and the HYPOTHALAMUS. It is also found in the skin and other peripheral tissues. Depending on species and tissues, POMC is cleaved by PROHORMONE CONVERTASES yielding various active peptides including ACTH; BETA-LIPOTROPIN; ENDORPHINS; MELANOCYTE-STIMULATING HORMONES; and others (GAMMA-LPH; CORTICOTROPIN-LIKE INTERMEDIATE LOBE PEPTIDE; N-terminal peptide of POMC or NPP).     
Examples Adrenocorticotropic Hormone; alpha-Endorphin; alpha-MSH; beta-Endorphin; beta-Lipotropin; beta-MSH; Corticotropin-Like Intermediate Lobe Peptide; gamma-Endorphin; gamma-Lipotropin; gamma-MSH; Melanocortins 		Other names Pro-Opiocortin; POMC; Pro Opiomelanocortin; Pro Opiocortin; Pro Opio Melanocortin; Pro ACTH Endorphin; Pre pro opiocortin; Pre POMC; Endorphin ACTH Precursor; Corticotropin beta Lipotropin Precursor; ACTH beta Lipotropin Precursor; ACTH Endorphin Precursor; Proopiomelanocortin; Proopiocortin; Pro-Opio-Melanocortin; Pro-ACTH-Endorphin; Preproopiomelanocortin; Pre-pro-opiocortin; Pre-POMC; Opiocortin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-POMC (1-28)  0   *Peptide Fragments *Pro-Opiomelanocortin Apoptosis Regulatory Proteins. Cell Tissue Res 2010 Aug;341(2):239-50
POMC protein, zebrafish  0   *Pro-Opiomelanocortin *Zebrafish Proteins. Biochem Biophys Res Commun 2003 Apr 18;303(4):1121-8
pro-opiomelanocortin (1-49)  0   *Peptide Fragments *Pro-Opiomelanocortin. Endocr Res 2000 Nov;26(4):523-9
pro-opiomelanocortin (1-77)  0   *Peptide Fragments *Pro-Opiomelanocortin. Endocr Res 2000 Nov;26(4):523-9
MSH, Lys-gamma(2)  0   *Peptide Fragments *Pro-Opiomelanocortin. Brain Res 1996 Aug 26;731(1-2):182-9
joining peptide, pro-opiomelanocortin  0   *Peptide Fragments *Pro-Opiomelanocortin. Biochem Biophys Res Commun 1992 Dec 15;189(2):691-6
pro-opiomelanocortin joining peptide(79-108)  83296-42-8   *Peptide Fragments *Pro-Opiomelanocortin. Peptides 1990;11(1):149
pro-opiomelanocortin joining peptide(77-97)  123723-76-2   *Peptide Fragments *Pro-Opiomelanocortin. J Biol Chem 1986;261(19):8686
pro-opiomelanocortin human joining peptide(77-109)  124222-22-6   *Peptide Fragments *Pro-Opiomelanocortin. Clin Invest Med 1985;8(2):167
pro-opiomelanocortin joining peptide(14-23)  88389-69-9 L-Argininamide, L-valyl-L-alanyl-L-valylglycyl-L-alpha-glutamylglycyl-L-prolylglycyl-L-prolyl  *Peptide Fragments *Pro-Opiomelanocortin. Peptides (Fayetteville) 1983;4(4):475
MSH, Lys-gamma(3)  83310-33-2 gamma3-Melanotropin, 14-L-proline-17-deglycine-21-L-alanine-22-deglycine-23-de-L-valine-26-L-serine  *Peptide Fragments *Pro-Opiomelanocortin. Endocrinology 1983;112(4):1279
pro-opiomelanocortin amino-terminal glycopeptide  0   *Peptide Fragments *Pro-Opiomelanocortin Aldosterone/metabolism. J Biol Chem 1981;256(15):7977
proopiocortin fragments  0   *Peptide Fragments *Pro-Opiomelanocortin. Acta Endocrinol (Copenh) 1980;95(1):27

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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