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Protein Methyltransferases
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Definition
: Enzymes that catalyze the methylation of amino acids after their incorporation into a polypeptide chain. S-Adenosyl-L-methionine acts as the methylating agent. EC 2.1.1.
do not confuse with PROTEIN O-METHYLTRANSFERASE; DF: note short X ref
Examples
Histone-Lysine N-Methyltransferase
;
O(6)-Methylguanine-DNA Methyltransferase
;
Protein-Arginine N-Methyltransferases
;
Protein O-Methyltransferase
Other names
Protein Methylases; Methyltransferases, Protein; Methylases, Protein
Substance
CAS Registry & name
Categories
Source
Drugs
*
SETD6 protein, human
EC 2.1.1.-
*Protein Methyltransferases.
Nat Immunol 2011 Jan;12(1):29-36
Setd7 protein, mouse
EC 2.1.1.-
*Protein Methyltransferases.
Mol Cell 2008 Feb 15;29(3):392-400
SETDB1 protein, mouse
EC 2.1.1.-
*Protein Methyltransferases.
Proc Natl Acad Sci U S A 2006 Dec 12;103(50):19176-81
Dart5 protein, Drosophila
EC 2.1.1.-
*Protein Methyltransferases
*Drosophila Proteins.
Curr Biol 2006 Jun 6;16(11):1077-89
Ste14 protein, S cerevisiae
EC 2.1.1.100
*Protein Methyltransferases
*Saccharomyces cerevisiae Proteins.
J Biol Chem 2005 Feb 25;280(8):7336-45
Skb1 protein, mouse
EC 2.1.1.-
*Protein Methyltransferases.
csul protein, Drosophila
EC 2.1.1.-
*Protein Methyltransferases
*Drosophila Proteins.
SETDB1 protein, human
EC 2.1.1.-
*Protein Methyltransferases.
Genes Dev 2002 Apr 15;16(8):919-32
Ppm1 protein, S cerevisiae
EC 2.1.1.-
*Protein Methyltransferases
*Saccharomyces cerevisiae Proteins.
Arch Biochem Biophys 2001 Nov 15;395(2):239-45
PRMT5 protein, human
EC 2.1.1.-
*Protein Methyltransferases.
J Biol Chem 1999 Oct 29;274(44):31531-42
farnesylthioacetic acid
0
Farnesol/*analogs & derivatives
Protein Methyltransferases/antagonists & inhibitors.
FEBS Lett 1998 Apr 24;426(3):319-24
prmC protein, E coli
EC 2.1.1.-
*Protein Methyltransferases
*Escherichia coli Proteins.
Gene 1995 Feb 3;153(1):67-70
protein-
S-
isoprenylcysteine O-
methyltransferase
EC 2.1.1.100
*Protein Methyltransferases.
Proc Natl Acad Sci USA 1988;85(13):4643
protein-
histidine methyltransferase
EC 2.1.1.-
*Protein Methyltransferases.
Biochim Biophys Acta 1987;923(1):156
cytochrome C-
methionine methyltransferase
EC 2.1.1.-
*Protein Methyltransferases.
J Biol Chem 1985;260(1):537
DNA-
dependent protein methylase
EC 2.1.1.-
*Protein Methyltransferases.
Biochemistry 14(20):4357;1975