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Quinidine

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Definition: An optical isomer of quinine, extracted from the bark of the Cinchona tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular action potential, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.     
Pharmacological Action Adrenergic alpha-Antagonists; Anti-Arrhythmia Agents; Antimalarials; Enzyme Inhibitors; Muscarinic Antagonists 		Other names Sulfate, Quinidine; Apo Quinidine; Robins Brand of Quinidine Sulfate; Quinora; Quinidine Sulfate; Quinidex; Quincardine; Nelson Brand of Quinidine Sulfate; Fawns & McAllan Brand of Quinidine Sulfate; Chinidin; Apotex Brand of Quinidine Sulfate; Apo-Quinidine; AdaquinDrugs* : QUINIDINE SULFATE; QUINIDEX; CIN-QUIN; QUINORA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
9-amino-9-deoxy-epi-hydroquinine  0   Quinidine/*analogs & derivatives. Chemistry. 2011 Dec 9;17(50):14267-72
tert-butylcarbamoylquinidine  0   Quinidine/*analogs & derivatives. Anal Bioanal Chem 2009 Jan;393(1):303-12
dextromethorphan - quinidine combination  0   *Dextromethorphan *Quinidine Drug Combinations. http://biz.yahoo.com/bw/061031/20061031005412.html?.v=1; Neurology. 2004 Oct 26;63(8):1364-70
quinidinium  0   Quinidine/*analogs & derivatives. J Pharmacol Exp Ther 2002 May;301(2):729-37
3-hydroxy-10,11-dihydroquinidine  130061-81-3 Cinchonan-3,9-diol, 10,11-dihydro-6'-methoxy-, (9S)-, sulfate (1:1) (salt)  Quinidine/*analogs & derivatives. J Cardiovasc Pharmacol 1990;16(3):506
10,11-dihydroxydihydroquinidine N-oxide  100182-37-4   Quinidine/*analogs & derivatives. J Nat Prod 1990;53(1):112
2'-oxoquinidinone  82793-82-6 Cinchonan-2',9(1'H)-dione, 6'-methoxy  Quinidine/*analogs & derivatives. Br J Clin Pharmacol 1987;23(3):351
quinidine polygalacturonate  27555-34-6   *Pectins *Quinidine Drug Combinations. G Ital Cardiol 1985;15(8):819CARDIOQUIN
quinidine-N-oxide  70116-00-6   *Cyclic N-Oxides Quinidine/*analogs & derivatives. Eur J Drug Metab Pharmacokinet 1984;9(4):315
3-hydroxydihydroquinidine  85405-60-3 Cinchonan-3,9-diol, 10,11-dihydro-6'-methoxy-, (3alpha,9S)  Quinidine/*analogs & derivatives. J Pharm Sci 1984;73(6):844
3-hydroxyhydroquinidine  85405-59-0 Cinchonan-3,9-diol, 10,11-dihydro-6'-methoxy-, (9S)  Quinidine/*analogs & derivatives. Arch Mal Coeur 1983;76(6):670
quinidine, verapamil drug combination  0   *Quinidine *Verapamil Drug Combinations. ZFA (Stuttgart) 1982;58(8):488
phenobarbital quinidine  1400-48-2   *Phenobarbital *Quinidine Drug Combinations. Med Clin (Barc) 1981;77(10):431
7'-trifluoromethyldihydrocinchonidine  38199-17-6   Quinidine/*analogs & derivatives. J Chromatogr 1980; 221(1):97
quinidine gluconate  7054-25-3   Quinidine/*analogs & derivatives.
Pharma Action Antimalarials 		Angiology 29(3):251;1978QUINACT; QUINAGLUTE; DURAQUIN; QUINALAN; QUINIDINE GLUCONATE; QUINATIME
hydroquinidine  1435-55-8   Quinidine/*analogs & derivatives.
Pharma Action Anti-Arrhythmia Agents ; Parasympatholytics 		Arzneim Forsch Drug Res 27(3):589;1977; Xenobiotica 1981;11(2):81
3-hydroxyquinidine  53467-23-5 6'-methoxycinchonan-3,9-diol  Quinidine/*analogs & derivatives. Cancer Treat Rep 60(8):1027;1976; Xenobiotica 1981;11(2):81
phenrytmat  78371-61-6 Cinchonan-9-ol, 6'-methoxy-, (9S)-, sulfate (2:1) (salt), mixt. with 5,5-diphenyl-2,4-imidazolidinedione and 10-(3-(4-methyl-1-piperazinyl)propyl)-10H-phenothiazine (Z)-2-butenedioate (1:2)  *Perazine *Phenytoin *Quinidine Drug Combinations. Med Welt 26(15):732;1975
quinidine bisulfate  747-45-5   *Quinidine. Kardiologiia (Moskva) 24(20):30;1974
ergotoxine, magnesium dehydrocholate, magnesium glutamate, magnesium nicotinate, quinidine sulfate, quinine sulfate, theobromine drug combination  0   *Ergolines *Magnesium *Quinidine *Quinine *Theobromine Drug Combinations. Medicina Arhiv 25(4-6):49;1971
quinidine arabogalactane sulfate  54692-74-9   Quinidine/*analogs & derivatives Delayed-Action Preparations. Lille Med 16(Suppl 1):234;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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