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Theobromine

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Definition: 3,7-Dimethylxanthine. The principle alkaloid in Theobroma cacao (the cacao bean) and other plants. A xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than THEOPHYLLINE and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, pp1318-9)  a bronchodilator & vasodilator alkaloid   
Pharmacological Action Bronchodilator Agents; Vasodilator Agents
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
chloro(theobrominato-N(1))bis(triphenylphosphine)platinum(II)  0   *Organoplatinum Compounds Theobromine/*analogs & derivatives. Acta Crystallogr C 2002 Feb;58(Pt 2):m111-5
7-methyl-8-(3-bromostyryl)-3,7-dimethyl-1-propargylxanthine  0   Theobromine/*analogs & derivatives. Ann Nucl Med 2000 Aug;14(4):247-53
7-methyl-3,7-dimethyl-8-(3-iodostyryl)-1-propargylxanthine  0   Theobromine/*analogs & derivatives. Ann Nucl Med 2000 Aug;14(4):247-53
guarana powder  0   *Caffeine *Theobromine *Theophylline Sapindaceae. Analyst 1994 Dec;119(12):2701-3
3,7-dimethyl-1-propargylxanthine  14114-46-6   Theobromine/*analogs & derivatives.
Pharma Action Adenosine A2 Receptor Antagonists
Life Sci 1988;43(21):1671
vitamin A, pentifyllin, nicotinic acid, and vitamin E combination  76584-56-0 Vitamin A, mixt. with 1-hexyl-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione, 3-pyridinecarboxylic acid and vitamin E  *Nicotinic Acids *Vitamin A *Vitamin E Drug Combinations Theobromine/*analogs & derivatives.
Pharma Action Vitamins
Med Welt 1980;31(35):1255
digoxin, nicotinic acid, pentifylline drug combination  0   *Digoxin *Nicotinic Acids Drug Combinations Theobromine/*analogs & derivatives. Ther Ggw 1979;118(11):1704
1-(beta,gamma-epoxypropyl)-8-bromotheobromine  16877-94-4 1H-Purine-2,6-dione, 8-bromo-3,7-dihydro-3,7-dimethyl-1-(oxiranylmethyl)  Theobromine/*analogs & derivatives. Acta Pol Pharm 35(4):417;1978
brondiletten retard  77124-30-2 Benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-(diethylamino)ethyl ester, hydrochloride, mixt. with 5-ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione, 1-hexyl-3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione and N,N,4-trimethyl-gamma-phenylbenzenepropana  *Benactyzine *Phenobarbital *Propylamines Drug Combinations Theobromine/*analogs & derivatives Delayed-Action Preparations. Med Monatsschr 29(11):513;1975; Med Welt 26(38):1733;1975; Ther Ggw 115(12):2104;1976
juston  77904-46-2   *Nicotinic Acids Drug Combinations Theobromine/*analogs & derivatives Vitamins. Munch Med Wsche 117(4):143;1975
theobromine magnesium oleate  6767-73-3   Theobromine/*analogs & derivatives.
pentifylline  1028-33-7 1-hexyl- 3,7-dimethylxanthine  Theobromine/*analogs & derivatives. Arzneim Forsch 1979;29(8):1089; Med Welt 26(38):1733;1975; Med Welt 29(19):808;1978; Wien Med Wochenschr 126(10):127;1976
gerocerebrin  52623-87-7 L-Glutamic acid, mixt. with adenosine 5'-(tetrahydrogen triphosphate), 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione, 3,7-dihydro-3,7-dimethyl-1H-purine-2,6-dione, 5-hydroxy-6-methyl-3,4-pyridinedimethanol hydrochloride and 3-pyridinecarboxylic acid  *Nicotinic Acids *Theobromine *Theophylline Drug Combinations Intracranial Arteriosclerosis/drug therapy. Farm Zh 28(6):79;1973
nicotinic acid, pentifylline drug combination  0   *Nicotinic Acids Drug Combinations Theobromine/*analogs & derivatives. Eur J Clin Pharmacol 11(3):181;1977; Opthalmologic 176(2):70;1978; Wiad Lek 28(18):1547;1975
lenigesial 1-carboxymethyl-3,7-dimethylxanthine  52387-20-9 1H-purine-1-acetic acid, 2,3,6,7-tetrahydro-3,7-dimethyl-2,6-dioxo-, compd. with (S-(R*,S*))-3-(dimethylamino)-2-methyl-1-phenyl-1-(phenylmethyl)propyl propanoate (1:1)  *Dextropropoxyphene Drug Combinations Theobromine/*analogs & derivatives. Minerva Anestesiol 38(1):28;1972; Minerva Anestesiol 38(5):297;1972
ergotoxine, magnesium dehydrocholate, magnesium glutamate, magnesium nicotinate, quinidine sulfate, quinine sulfate, theobromine drug combination  0   *Ergolines *Magnesium *Quinidine *Quinine *Theobromine Drug Combinations. Medicina Arhiv 25(4-6):49;1971

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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