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Ribonucleoside Diphosphate Reductase

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Definition: An enzyme of the oxidoreductase class that catalyzes the formation of 2'-deoxyribonucleotides from the corresponding ribonucleotides using NADPH as the ultimate electron donor. The deoxyribonucleoside diphosphates are used in DNA synthesis. (From Dorland, 27th ed) EC 1.17.4.1.      Other names Reductase, UDP; Reductase, Ribonucleoside Diphosphate; Diphosphate Reductase, Ribonucleoside; UDP Reductase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Rnr4 protein, S cerevisiae  EC 1.17.4.1   *Ribonucleoside Diphosphate Reductase *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1997 Oct;17(10):6114-21
RNR3 protein, S cerevisiae  EC 1.17.4.1   *Ribonucleoside Diphosphate Reductase *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1990 Oct;10(1):5553-7
NrdA protein, E coli  EC 1.17.4.1   *Ribonucleoside Diphosphate Reductase *Escherichia coli Proteins. J Bacteriol 2002 Feb;184(4):895-903
NrdI protein, Mycoplasma gallisepticum  EC 1.17.4.1   *Bacterial Proteins *Ribonucleoside Diphosphate Reductase. FEMS Microbiol Lett 2001 Jun 12;200(1):31-5
ribonucleotide reductase M2  EC 1.17.4.-   *Ribonucleoside Diphosphate Reductase. Genomics 1995 Feb 10;25(3):644-9
2'-deoxy-2'-(fluoromethylene)cytidine  130306-02-4 Cytidine, 2'-deoxy-2'-(fluoromethylene)-, (2E)  Deoxycytidine/*analogs & derivatives Ribonucleoside Diphosphate Reductase/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors ; Radiation-Sensitizing Agents 		Cancer Res 1994 Mar 15;54(6):1485-90
2'-C-methyluridine diphosphate  150993-73-0   Uridine Diphosphate/*analogs & derivatives Ribonucleoside Diphosphate Reductase/antagonists & inhibitors. Biochemistry 1993 Oct 36;32(42):11397-404
2'C-methyladenosine 5'-diphosphate  150993-72-9   Adenosine Diphosphate/*analogs & derivatives Ribonucleoside Diphosphate Reductase/antagonists & inhibitors. Biochemistry 1993 Oct 26;32(42):11397-404
ADP reductase  EC 1.17.4.-   *Ribonucleoside Diphosphate Reductase. Arch Biochem Biophys 1982;217(2):546
CDP reductase  EC 1.17.4.-   *Ribonucleoside Diphosphate Reductase. Cancer Res 37:1868;1977; Nucleic Acids Res 6(1):305;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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