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Steroid 11-beta-Hydroxylase

More information in Books or onNLM PubMed
Definition: A mitochondrial cytochrome P450 enzyme that catalyzes the 11-beta-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of CORTICOSTERONE and HYDROCORTISONE. Defects in CYP11B1 cause congenital adrenal hyperplasia (ADRENAL HYPERPLASIA, CONGENITAL).     
See Also Adrenal Hyperplasia, Congenital 		Other names Steroid 11-beta-Monooxygenase; Cytochrome P-450(11 beta); Cytochrome P-450 CYP11B1; CYP11B1; Steroid 11 beta Monooxygenase; Steroid 11 beta Hydroxylase; Cytochrome P 450 CYP11B1; 11 beta Hydroxylase; Steroid-11-Hydroxylase; Steroid 11-Hydroxylase; Steroid 11 Hydroxylase; Cytochrome P450 11B1; 11 beta-Hydroxylase; CYP 11B1
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4'-(pyridin-4-ylmethyl)biphenyl-3-amine  0   *Biphenyl Compounds *Pyridines Steroid 11-beta-Hydroxylase/antagonists & inhibitors Steroid 17-alpha-Hydroxylase/antagonists & inhibitors. J Med Chem 2010 Aug 12;53(15):5749-58

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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