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Tetrahydrofolates

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Definition: Compounds based on 5,6,7,8-tetrahydrofolate.  deficiency: coordinate TETRAHYDROFOLATES /defic (IM) with FOLIC ACID DEFICIENCY (IM)   
Pharmacological Action Vitamin B Complex
Examples Formyltetrahydrofolates
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
beyaz  0   *Androstenes *Ethinyl Estradiol *Tetrahydrofolates Contraceptives, Oral, Combined. Womens Health (Lond Engl). 2012 Jan;8(1):13-9.BEYAZ; SAFYRAL
10-methanesulfonyl-DDACTHF  0   *Tetrahydrofolates. Bioorg Med Chem. 2005 May 16;13(10):3577-85
10-methylthio-DDACTHF  0   *Tetrahydrofolates. Bioorg Med Chem. 2005 May 16;13(10):3577-85
10-methanesulfonyl-5-DACTHF  0   *Tetrahydrofolates. Bioorg Med Chem. 2005 May 16;13(10):3577-85
BW 2315  0   *Sulfonamides *Tetrahydrofolates Tetrahydrofolate Dehydrogenase/antagonists & inhibitors Thymidylate Synthase/antagonists & inhibitors. J Biol Chem 2004 Apr 23;279(17):18034-45
BW 1540  0   *Sulfonamides *Tetrahydrofolates Tetrahydrofolate Dehydrogenase/antagonists & inhibitors Thymidylate Synthase/antagonists & inhibitors. J Biol Chem 2004 Apr 23;279(17):18034-45
10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid  0   *Tetrahydrofolates. Bioorg Med Chem 2003 Oct 1;11(20):4503-9
10-formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid  0   *Tetrahydrofolates. Bioorg Med Chem. 2002 Aug;10(8):2739-49
10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid  0   *Tetrahydrofolates. Biochemistry 2003 May 27;42(20):6043-56
tetrahydrofolate polyglutamate  0   Polyglutamic Acid/*analogs & derivatives Tetrahydrofolates. Biochemistry 2000 Apr 18;39(15):4259-66
5-methyltetrahydrofolate pentaglutamate  0   *Pteroylpolyglutamic Acids *Tetrahydrofolates. J Biol Chem 1999 Dec 31;274(53):37559-64
6R-2',5'-thienyl-5,10-dideazatetrahydrofolic acid  0   *Tetrahydrofolates. Invest New Drugs 1996;14(3):287-94
N- ((5-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)-2-thiazolyl)carbonyl)glutamic acid  158010-69-6   *Tetrahydrofolates. J Med Chem 1994 Jun 24;37(13):2112-5
N-((5-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)-2-thienoyl)carbonyl)glutamic acid  158010-68-5   *Tetrahydrofolates. J Med Chem 1994 Jun 24;37(13):2112-5
5,11-methylenetetrahydro-5-deazahomofolic acid  130985-82-9   *Tetrahydrofolates Thymidylate Synthase/antagonists & inhibitors. J Med Chem 1991;34(2):611
5-deaza-5,6,7,8-tetrahydroisofolic acid  130327-70-7   *Tetrahydrofolates. J Med Chem 1991;34(2):606
N-(4-((3-(2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl)amino)benzoyl)glutamic acid  118252-44-1   *Tetrahydrofolates. J Med Chem 1990;33(2):561
5-deaza-5,6,7,8-tetrahydrofolic acid  115587-73-0   *Tetrahydrofolates. J Med Chem 1989;32(7):1517
5,8,10-trideaza-5,6,7,8-tetrahydrofolate  118537-33-0   *Tetrahydrofolates. J Med Chem 1989;32(3):709
5,6,7,8-tetrahydro-8-deazahomofolic acid  111113-75-8   *Tetrahydrofolates. J Med Chem 1988;31(1):150
N(10)-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid  107174-40-3   *Tetrahydrofolates. J Med Chem 1987;30(7):1256
lometrexol  95693-76-8   *Tetrahydrofolates.
Pharma Action Antimetabolites, Antineoplastic ; Folic Acid Antagonists 		J Med Chem 1985;28(7):914
5,10-methylenetetrahydrofolate polyglutamate  85917-14-2 L-Glutamic acid, N-(N-(N-(N-(N-(N-(N-(N-(4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo(1,5-f)pteridin-8(9H)-yl)benzoyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)  *Tetrahydrofolates. Biochim Biophys Acta 1983;756(3):253
5-methyltetrahydrofolate triglutamate  50998-20-4 L-Glutamic acid, N-(N-(N-(N-(4-(((2-amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-gamma-glutamyl)-L-gamma-glutamyl)-L-gamma-glutamyl)  *Tetrahydrofolates. Br J Cancer 1983;47(3):393
5,6,7,8-tetrahydro-8-deazafolic acid  51989-29-8   *Tetrahydrofolates. J Med Chem 1981;24(10):1254
5,6,7,8-tetrahydrofolic acid  29347-89-5   *Tetrahydrofolates. J Biol Chem 1981;256(12):6245
4a-hydroxy-5-methyltetrahydrofolic acid  33157-07-2 L-glutamic acid, N-(4-(((2-amino-3,4,4a,5,6,7-hexahydro-4a-hydroxy-5-methyl-4-oxo-6-pteridinyl)methyl)amino)benzoyl)  *Tetrahydrofolates. Biochem Soc Trans 7(4):646;1979
5,10-methenyltetrahydrofolate  7444-29-3   *Tetrahydrofolates. Arch Biochem Biophys 189(2):283;1978
5,10-methylenetetrahydrofolate  3432-99-3 N-(4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo(1,5-f)pteridin-8(9H)-yl)benzoyl)-L-glutamic acid  *Tetrahydrofolates. Arch Biochem Biophys 185(2):448;1978; Biochem Biophys Res Commun 72(2):404;1976; Biochem Biophys Res Commun 86(2):244;1979; Biochem J 178(1):165;1979; Biochemistry 17(19):4018;1978; Biochemistry 1979;18(24):5227; J Parasitol 1980;66(1):53; Postepy Biochem 24(1):93;1978
5-methyltetrahydrofolate  134-35-0   *Tetrahydrofolates. Am J Physiol 229(3):777;1975; Anal Biochem 83:615;1978; Anal Biochem 92(2):366;1979; Arch Biochem Biophys 1979;196(2):557; Biochem Soc Trans 7(4):648;1979; Cancer Res 38(11):3847;1978; Cancer Res 38(11):3966;1978; Epilepsia 17:223;1976; Folic acid in neurology, psychiatry, and internal medicine WD 120 F665 1979:157; Folic acid in neurology, psychiatry, and internal medicine WD 120 F665 1979:213; Folic acid in neurology, psychiatry, and internal medicine WD 120 F665 1979:317; J Bacteriol 134(2):506;1978; J Biol Chem 1979;254(21:10881; J Clin Invest 52(9):2138;1973; J Clin Invest 61(5):1270;1978; J Lab Clin Med 86(5):834;1975; J Lab Clin Med 94(2):354;1979; J Nucl Med 19(8):906;1978; J Nutr 1980;110(2):223

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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