Definition: Inhibitors of the enzyme, dihydrofolate reductase (TETRAHYDROFOLATE DEHYDROGENASE), which converts dihydrofolate (FH2) to tetrahydrofolate (FH4). They are frequently used in cancer chemotherapy. (From AMA, Drug Evaluations Annual, 1994, p2033)
DF: FOLIC ACID ANTAG
Other names Antifolates; Antagonists, Folic Acid; Acid Antagonists, Folic