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Dapsone

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Definition: A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8)     
Pharmacological Action Antimalarials; Anti-Infective Agents; Folic Acid Antagonists; Leprostatic Agents
Examples Acedapsone 		Other names Diaminodiphenylsulfone; Sulfonyldianiline; Sulfone, 4,4'-Diaminophenyl; 4,4' Diaminophenyl Sulfone; Sulfona; Orsade Brand of Dapsone; Mex-America Brand of Dapsone; Fatol Brand of Dapsone; Disulone; Diaphenylsulfone; Dapson-Fatol; Dapsoderm-X; DADPS; Avlosulfone; 4,4'-Diaminophenyl SulfoneDrugs* : DAPSONE; ACZONE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
chloroguanil, dapsone drug combination  0   *Dapsone Proguanil/*analogs & derivatives Drug Combinations. JAMA. 2007 May 23;297(20):2201-9
diformyl dapsone  6784-25-4   Dapsone/*analogs & derivatives.
monoacetyldapsone hydroxylamine  32604-86-7   Dapsone/*analogs & derivatives. Drug Metab dispos 1994 Jul-Aug;22(4):572-7
4'-amino-4-n-propylamino-2-methyldiphenylsulfone  101513-21-7   Dapsone/*analogs & derivatives. Arzneimittelforschung 1989;39(9):1073
4-nitro-4'-aminodiphenyl sulfone  1948-92-1 Benzenamine, 4-((4-nitrophenyl)sulfonyl)  Dapsone/*analogs & derivatives. J Pharmacol Exp Ther 1988;245(1):274
4,4'-dibutyrylaminodiphenyl sulfone  59429-40-2   Dapsone/*analogs & derivatives. Indian J Lepr 1985;57(4):756
4,4'-disuccinoylaminodiphenyl sulfone  14052-68-7   Dapsone/*analogs & derivatives. Indian J Lepr 1985;57(4):756
monolauryldapsone  21501-04-2   Dapsone/*analogs & derivatives. J Pharm Soc 1986;75(3):264
dapsone, methyluracil drug combination  69422-71-5   *Dapsone Drug Combinations Uracil/*analogs & derivatives. Vestn Dermatol Venerol 1983;(12):19
glucosulfone  551-89-3   Dapsone/*analogs & derivatives. Indian J Chest Dis Allied Sci 1982;24(2-3):179
sulfoxone  144-76-3   Dapsone/*analogs & derivatives. Arch Dermatol 1982;118(10):805DIASONE SODIUM
monoacetyldapsone  565-20-8 N-(4-((4-aminophenyl)sulfonyl)phenyl)acetamide  Dapsone/*analogs & derivatives.
Pharma Action Anti-Infective Agents 		Acta Paediatr Scand 1980;69(1):31; Am J Trop Med Hyg 26(1):127;1976; Anal Chem 45(6):916;1973; Arthritis Rheumat 21(2):192;1978; J Chromatogr 1979;163(2):179; Proc Soc Exp Biol Med 150(2):485;1975
4-amino-4'-hydroxylaminodiphenylsulfone  32695-27-5   Dapsone/*analogs & derivatives. Br J Haematol 40(2):219;1978
Novolep  78355-45-0 Novolep  *Dapsone Drug Combinations. Indian J Dermatol 21(1):22;1975
isoprodian  55015-10-6 4-pyridinecarboxylic acid hydrazide mixture with 2-propyl-4-pyridinecarbothioamide and 4,4'-sulfonylbis(benzenamine)  *Dapsone *Isoniazid *Prothionamide Drug Combinations. Chemotherapy 24():187;1978; Jpn J Lepr 47(1):43;1978; Lepr Rev 46(suppl 2):161-207;1975; Med Cutan Iber Lat Am 4(5):365;1976; Prax Klin Pneumol 30(4):224;1976; Prax Klin Pneumol 30(7):430;1976; Prax Klin Pneumol 30(7):435;1976; Prax Klin Pneumol 30:584;1976; Prax Klin Pneumol 31:116;1977; Scand J Respir Dis (Suppl 102):58;1978; Scand J Respir Dis (Suppl 102):60;1978
4-amino-p'-ureidodiphenylsulfone  3569-77-5   Dapsone/*analogs & derivatives. Poultry Sci 53(4):1533;1974
SDDS  17615-73-5   Dapsone/*analogs & derivatives. Can Vet J 18(3):51;1977; Indian J Med Res 67:908;1978; Tropenmed Parasitol 28:528;1977
Maloprim  37357-69-0   *Dapsone *Pyrimethamine Drug Combinations.
Pharma Action Antimalarials 		J Chromatogr 1979;163(2):179; Southeast Asian J Trop Med Public Health 2(1):42;1971

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