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20-Hydroxysteroid Dehydrogenases
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Definition
: A group of enzymes that catalyze the reversible reduction-oxidation reaction of 20-hydroxysteroids, such as from a 20-ketosteroid to a 20-alpha-hydroxysteroid (EC 1.1.1.149) or to a 20-beta-hydroxysteroid (EC 1.1.1.53).
do not confuse with 20-BETA-HYDROXYSTEROID DEHYDROGENASE (see CORTISONE REDUCTASE)
Examples
20-alpha-Hydroxysteroid Dehydrogenase
;
Cortisone Reductase
Other names
Hydroxysteroid Dehydrogenases, 20; Dehydrogenases, 20-
Hydroxysteroid; Dehydrogenases, 20 Hydroxysteroid; 20 Hydroxysteroid Dehydrogenases
Substance
CAS Registry & name
Categories
Source
Drugs
*
3 alpha-
beta, 20 beta-
hydroxysteroid dehydrogenase
EC 1.1.1.-
*20-Hydroxysteroid Dehydrogenases.
Biochem J 1998 Sep 15;334( Pt 3):553-7
progesterone 20-
keto-
reductase
EC 1.1.1.-
*Cytochrome P-450 Enzyme System
*20-Hydroxysteroid Dehydrogenases.
Biochem Biophys Res Commun 1992 Apr 15;184(1):338-46
1-
(3-
hydroxyandrostan-
17-
yl)-
2-
propen-
1-
one
0
*Androstanols
20-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
Biochem J 1986 Dec 15;240(3):717-23
16-
methylene estradiol
7627-87-4 Estra-
1,3,5(10)-
triene-
3,17-
diol, 16-
methylene-
, (17beta)
Estradiol/*analogs & derivatives
20-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
J Biol Chem 1983;258(19):11500
16-
methylene estrone
10506-73-7 Estra-
1,3,5(10)-
trien-
17-
one, 3-
hydroxy-
16-
methylene
Estrone/*analogs & derivatives
20-Hydroxysteroid Dehydrogenases/antagonists & inhibitors.
J Biol Chem 1983;258(19):11500