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Inositol 1,4,5-Trisphosphate

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Definition: Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make up the cell membrane. Inositol 1,4,5-trisphosphate is released into the cytoplasm where it releases calcium ions from internal stores within the cell's endoplasmic reticulum. These calcium ions stimulate the activity of B kinase or calmodulin.      Other names Myo-Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Triphosphate; 1,4,5-InsP3; Myoinositol 1,4,5-Triphosphate; 1,4,5-IP3
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
WH 15 compound  0   *Aminoquinolines Inositol 1,4,5-Trisphosphate/*analogs & derivatives. ACS Chem Biol 2011 Mar 18;6(3):223-8
2-O-(4'-(N-9''-purinyl)butyl) myo-inositol 1,4,5-tris(phosphate)  0   *Purines Inositol 1,4,5-Trisphosphate/*analogs & derivatives. J Med Chem 2005 Feb 24;48(4):1251-5
xestospongin A  0   *Oxazoles *Macrocyclic Compounds Calcium Channels Inositol 1,4,5-Trisphosphate. Neuron 1997 Sep;19(3):723-33
1-O-(3-(4-benzoyldihydrocinnamidiyl)propyl)-myoinositol 1,4,5-trisphosphate  0   *Benzophenones Inositol 1,4,5-Trisphosphate/*analogs & derivatives. Biochemistry 1996 Jun 10;36(23):7239-48
inositol 2,3,5-trisphosphorothioate  0   *Organothiophosphorus Compounds Inositol 1,4,5-Trisphosphate/*analogs & derivatives. Bioorg Med Chem 1994 Apr;2(4):253-7
inositol 1,4,6-trisphosphorothioate  0   *Organothiophosphorus Compounds Inositol 1,4,5-Trisphosphate/*analogs & derivatives. Biochem Biophys Res Commun 1994 Apr 15;200(1):8-15
inositol 1,4,6-trisphosphate  114418-85-8   Inositol 1,4,5-Trisphosphate/*analogs & derivatives. Biochem Biophys Res Commun 1994 Apr 15;200(1):8-15
3-amino-3-deoxy-myo-inositol 1,4,5-trisphosphate  153212-81-8   Inositol 1,4,5-Trisphosphate/*analogs & derivatives. J Med Chem 1994 Mar 18;37(6):868-72
3-deoxy-3-fluoroinositol 1,4,5-trisphosphate  144371-38-0   Inositol 1,4,5-Trisphosphate/*analogs & derivatives. J Physiol (Lond) 1993 Aug;468:275-96
6-deoxyinositol 1,4,5-triphosphate  124501-87-7   Inositol 1,4,5-Trisphosphate/*analogs & derivatives. FEBS Lett 1991;278(2):252
2,2-difluoro-2-deoxy-inositol 1,4,5-trisphosphate  132488-75-6   Inositol 1,4,5-Trisphosphate/*analogs & derivatives. FEBS Lett 1990;276(1-2):91
2-deoxy-2-fluoroinositol 1,4,5-trisphosphate  132489-75-9   Inositol 1,4,5-Trisphosphate/*analogs & derivatives. FEBS Lett 1990;276(1-2):91
inositol 1,4,5-trisphosphate 1-(2-nitrophenyl)ethyl ester  119147-21-6   Inositol 1,4,5-Trisphosphate/*analogs & derivatives. J Neurosci 1989;9(11):4068
inositol 1,4,5-triphosphorothioate  113596-09-1   *Organothiophosphorus Compounds Inositol 1,4,5-Trisphosphate/analogs & derivatives. Biochem Biophys Res Commun 1988;150(2):626

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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