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Macrocyclic Compounds

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Definition: Cyclic compounds with a ring size of approximately 1-4 dozen atoms.  general or unspecified; prefer specific group or specific compound   
Examples Calixarenes; Crown Compounds; Cyclodextrins; Cycloparaffins; Ethers, Cyclic; Lactams, Macrocyclic; Peptides, Cyclic; Polyketides; Tetrapyrroles; Trichothecenes 		Other names Compounds, Macrocyclic; Compounds, Macrocycle; Torands; Spherands; Macrocycle Compounds
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
oxacyclohexadec-12(13)-en-2-one  0   *Ketones *Macrocyclic Compounds. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S152-7
4-cyclopentadecen-1-one  0   *Ketones *Macrocyclic Compounds. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S112-6
cyclohexadec-8-en-1-one  0   *Ketones *Macrocyclic Compounds. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S109-11
5-cyclohexadecen-1-one  0   *Ketones *Macrocyclic Compounds. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S98-103
cycloheptadeca-9-en-1-one  0   *Ketones *Macrocyclic Compounds. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S93-7
3-methylcyclopentadecenone  0   *Ketones *Macrocyclic Compounds. Food Chem Toxicol. 2011 Dec;49 Suppl 2():S85-92
metacridamide B  0   *Macrocyclic Compounds. J Nat Prod. 2012 Feb 24;75(2):175-80
metacridamide A  0   *Macrocyclic Compounds. J Nat Prod. 2012 Feb 24;75(2):175-80
bambus(6)uril  0   *Imidazoles *Macrocyclic Compounds. J Phys Chem A. 2011 Oct 20;115(41):11378-86
10'-bis(acetamido)ethane-bis(1,4,7-tri(carboxymethane)-1,4,7,10-tetraazacyclododecane)  0   *Macrocyclic Compounds. Dalton Trans. 2011 Apr 7;40(13):3346-51
9'-epi-3beta,3'beta-dimethylxestospongin C  0   *Diamines *Macrocyclic Compounds Alkaloids. Planta Med. 2011 Jan;77(2):179-81
incednam  0   *Macrocyclic Compounds. Org Lett. 2010 Nov 5;12(21):5068-71
JNJ-26483327  0   *Macrocyclic Compounds. Br J Cancer. 2010 Sep 28;103(7):987-92
haliclonacyclamine C  0   *Piperidines *Macrocyclic Compounds. Angew Chem Int Ed Engl. 2010 Feb 22;49(9):1599-602
trans-3,3'-dihydroxy-1,5,1',5'-tetrathiacyclodecane  0   *Macrocyclic Compounds. Phytochemistry. 2009 Dec;70(17-18):2096-100
22-hydroxyhaliclonacyclamine B  0   *Piperidines *Macrocyclic Compounds. Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1136-8
symbiodinolide  0   *Macrocyclic Compounds. J Org Chem. 2009 Jul 3;74(13):4797-803
aspercyclide B  0   *Lactones *Macrocyclic Compounds. Chemistry. 2009 Jun 8;15(24):5956-68
aspercyclide A  0   *Lactones *Macrocyclic Compounds. Chemistry. 2009 Jun 8;15(24):5956-68
cyclotrehalan  0   *Macrocyclic Compounds. J Org Chem. 2009 Apr 17;74(8):2997-3008
haliclonin A  0   *Diamines *Macrocyclic Compounds. Org Lett 2009 Apr 16;11(8):1713-6
isoplagiochin B  0   *Macrocyclic Compounds. Bioorg Med Chem Lett. 2009 Jan 15;19(2):493-6
isoplagiochin A  0   *Macrocyclic Compounds. Bioorg Med Chem Lett. 2009 Jan 15;19(2):493-6
tetralactam macrocycle  0   *Lactams *Macrocyclic Compounds. Chemistry. 2008;14(32):10012-28
N,N'-Bis((6-carboxy-2-pyridyl)methyl)-1,7-diaza-12-crown-4  0   *Macrocyclic Compounds Ligands. Inorg Chem. 2008 Sep 1;47(17):7840-51
oxacyclododecindione  0   *Macrocyclic Compounds. J Antibiot (Tokyo). 2008 May;61(5):285-90
TZP-101  0   *Macrocyclic Compounds. J Clin Pharmacol 2008 Feb;48(2):193-202
tetraaza(6.1.6.1)paracyclophane  0   *Aza Compounds *Macrocyclic Compounds. J Am Chem Soc. 2007 Nov 7;129(44):13698-705
syphonoside  0   *Terpenes *Macrocyclic Compounds. J Org Chem 2007 Jul 20;72(15):5625-30
sorangiolide B  0   *Lactones *Macrocyclic Compounds. Org Lett 2007 Jun 7;9(12):2273-6
tetramethylcucurbit(6)uril  0   *Macrocyclic Compounds. J Phys Chem A 2007 Apr 12;111(14):2715-21
gymnorrhizol  0   *Disulfides *Macrocyclic Compounds. Org Lett 2007 Apr 26;9(9):1715-6
floresolide B  0   *Macrocyclic Compounds. Chem Commun (Camb) 2006 Feb 14;(6):600-2
aspercyclide C  0   *Lactones *Macrocyclic Compounds. Chem Commun (Camb). 2005 Nov 28;(44):5583-5
(R,Z)-5-muscenone  0   *Ketones *Macrocyclic Compounds. Angew Chem Int Ed Engl. 2007;46(8):1307-10
iron-3,3,6,6,9,9-hexamethyl-3,4,8,9-tetrahydro-1H-1,4,8,11-benzotetraazacyclotridecine-2,5,7,10(6H,11H)-tetraone  0   *Macrocyclic Compounds *Iron Compounds. Science 2007 Feb 9;315(5813):835-8
cucurbituril  0   *Macrocyclic Compounds. Angew Chem Int Ed Engl. 2005 May 30;44(22):3402-7
octaamine 1  0   *Polyamines *Macrocyclic Compounds. Bioconjug Chem. 2006 Jan-Feb;17(1):132-8
phelligridimer A  0   *Pyrones *Macrocyclic Compounds. Org Lett 2005 Oct 13;7(21):4733-6
xestospongin C  0   *Oxazoles *Macrocyclic Compounds.
18-diazo-1,4,7,10,13,16-hexaoxacyclononadeca-17,19-dione  0   *Azo Compounds *Macrocyclic Compounds. J Org Chem. 2005 Nov 25;70(24):9867-73
trianglimine  0   *Macrocyclic Compounds. Org Biomol Chem. 2005 Feb 7;3(3):524-37
radanamycin  0   *Macrocyclic Compounds. Bioorg Med Chem Lett. 2006 May 1;16(9):2459-62
tonantzitlolone  0   *Diterpenes *Macrocyclic Compounds. Org Lett. 2005 Feb 3;7(3):479-82
carceplex  0   *Macrocyclic Compounds. J Am Chem Soc. 2005 Sep 7;127(35):12363-7
cyclo(-6)-glucopyranosyl-1-4-glucopyranosyl-1-6-glucopyranosyl-1-4-glucopyranosyl-(1-)  0   *Oligosaccharides *Macrocyclic Compounds. Carbohydr Res 2005 Jun 13;340(8):1469-74
cyclo(-6)-glucpyranosyl-1-3-glucopyranosyl-1-6-glucopyranosyl-1-3-(glucopyranosyl-1-6)-glucopyranosyl-1-4-glucopyranosyl-(1-)  0   *Oligosaccharides *Macrocyclic Compounds. Carbohydr Res 2005 Jul 4;340(9):1577-82
cyclo(-6)-glucpyranosyl-1-3-glucopyranosyl-1-6-glucopyranosyl-1-3-glucopyranosyl-1-4-glucopyranosyl-(1-)  0   *Oligosaccharides *Macrocyclic Compounds. Carbohydr Res 2005 Jul 4;340(9):1577-82
2,9-dipropyl-3,10-dimethyl-1,4,8,11-tetraaza-5,7-12,14-dibenzocyclotetradeca-1,3,8,10-tetraene  0   *Aza Compounds *Macrocyclic Compounds. Spectrochim Acta A Mol Biomol Spectrosc. 2005 Apr;61(6):1181-8
4-octasulfophenylpyrazinoporphyrazine  0   *Pyrazines *Macrocyclic Compounds. Dalton Trans. 2004 Feb 7;(3):429-35
(RSSR)-1,9-dibenzyl-3,7,11,15-tetramesityl-1,9-diaza-3,7,11,15-tetraphosphacyclohexadecane  0   *Phosphines *Macrocyclic Compounds. Dalton Trans. 2004 Feb 7;(3):357-8
BILN 2061  0   *Carbamates *Quinolines *Thiazoles *Macrocyclic Compounds. Nature 2003 Nov 13;426(6963):186-9
dracophane  0   *Phenols *Macrocyclic Compounds. Phytochemistry 2002 Dec;61(8):967-70
arenosclerin C  0   *Alkaloids *Piperidines *Macrocyclic Compounds. J Nat Prod 2000 Aug;63(8):1098-105
arenosclerin B  0   *Alkaloids *Piperidines *Macrocyclic Compounds. J Nat Prod 2000 Aug;63(8):1098-105
arenosclerin A  0   *Alkaloids *Piperidines *Macrocyclic Compounds. J Nat Prod 2000 Aug;63(8):1098-105
haliclonacyclamine E  0   *Alkaloids *Piperidines *Macrocyclic Compounds. J Nat Prod 2000 Aug;63(8):1098-105
PF 1163B  0   *Macrocyclic Compounds. J Antibiot (Tokyo) 1999 Dec;52(12):1146-51
PF 1163A  0   *Macrocyclic Compounds. J Antibiot (Tokyo) 1999 Dec;52(12):1146-51
haliclonacyclamine B  0   *Alkaloids *Piperidines *Macrocyclic Compounds. Cell Tissue Res 1998 Aug;293(2):365-73
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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