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ψ
Enkephalin, Leucine-2-Alanine
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Definition
: A delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.
DF: DADLE
Other names
Leucine Enkephalin-
2-
Alanine; Enkephalin-
Leu,Ala(2); D-
Ala(2)-
D-
Leu(5)-
Enkephalin; 5-
Leucine-
2-
Alanine Enkephalin; 2-
Alanyl-
Leucine Enkephalin; Leucine-
2-
Alanine Enkephalin; Leucine Enkephalin 2 Alanine; Leu Enkephalin 2 Ala; Enkephalin-
2-
Alanine, Leucine; Enkephalin, Leucine 2 Alanine; Enkephalin, 5-
Leucine-
2-
Alanine; Enkephalin, 2-
Alanyl-
Leucine; BW180C; BW 180C; 5 Leucine 2 Alanine Enkephalin; 2 Alanyl Leucine Enkephalin; Leu-
Enkephalin-
2-
Ala; DADLE; BW-
180C
Substance
CAS Registry & name
Categories
Source
Drugs
*
dalargin, destyrosyl
0
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Bull Exp Biol Med 2004 Jan;137(1):27-30
enkephalin-
Leu-
polyethylene glycol, Ala(2)
0
*Polyethylene Glycols
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Biol Pharm Bull 1994 Jun;17(6):823-5
enkephalin-
Leu, Ala(2)-
Ser(6)
132930-82-6
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Eur J Pharmacol 1991;192(3):371
enkephalin-
Leu methyl ester, Ala(2)-
cyclopropyl-
Phe(4)
117783-82-1
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Eur J Pharmacol 1990;177(1-2)99
enkephalin-
Leu, (Ala(2)-
Cl-
Phe(4))
77062-77-2
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Int J Pept Protein Res 1987;30(4):489
enkephalin-
Leu, Ala(2)-
(cyclopropyl-
Phe)(4)
88466-08-4
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
FEBS Lett 1987;222(1):71
enkephalin-
Leu, Ala(2)-
Cys(6)
110881-59-9
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Pharma Action
Affinity Labels
J Biol Chem 1987;262(28):13434
enkephalin-
Leu, Ala(2)-
cystamine-
dimer
99043-48-8
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Int J Pept Protein Res 1986;27(2):153
tyrosyl-
alanyl-
glycyl-
phenylalanyl-
psi(thiomethylene)leucine
103834-43-1
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Biochem Biophys Res Commun 1986;136(2):730
enkephalin-
Leu, N,N-
diallyl-
Ala(2)-
bis(cystine)(6)
93450-55-6
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Jpn J Pharmacol 1984;36(4):485
enkephalin-
Leu, N,N-
diallyl-
Ala(2)
88285-66-9
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Jpn J Pharmacol 1984;36(4):485
enkephalinamide-
Leu, Ala(2)-
N-
(2-
((4-
azido-
2-
nitrophenyl)amino)N-
ethyl(5))
83544-71-2 L-
Leucinamide, L-
tyrosyl-
D-
alanylglycyl-
L-
phenylalanyl-
N-
(2-
((4-
azido-
2-
nitrophenyl)amino)ethyl)-
, (2S-
(1(R*(R*)),2R*))
*Azides
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
J Med Chem 1984;27(7):836
enkephalin-
Leu, Ala(2)-
Me-
Phe(4)
64963-13-9 L-
Leucine, N-
(N-
(N-
methyl-
N-
(N-
L-
tyrosyl-
D-
alanyl)glycyl)-
L-
phenylalanyl)-
, (3S-
(3alpha,4abeta,5beta,6beta,6aalpha,10alpha,10abeta,10balpha))
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Life Sci 1984;34(21):2015
enkephalin-
Leu, Ala(2)-
Arg(6)
81733-79-1
Enkephalin, Leucine-2-Alanine/*analogs & derivatives
Nerve Growth Factors.
Pharma Action
Adjuvants, Immunologic
;
Analgesics
;
Anti-Arrhythmia Agents
;
Anti-Inflammatory Agents, Non-Steroidal
;
Anti-Ulcer Agents
;
Antioxidants
;
Gastrointestinal Agents
;
Sympatholytics
Biull Eksp Biol Med 184;97(3):261
enkephalin-
Leu, Ala(2)-
melphalan methyl ester
88457-22-1 L-
Phenylalanine, 4-
(bis(2-
chloroethyl)amino)-
N-
(N-
(N-
(N-
(N-
L-
tyrosyl-
D-
alanyl)glycyl)-
L-
phenylalanyl)-
L-
leucyl)-
, methyl ester
Melphalan/*analogs & derivatives
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Life Sci 1983;33 suppl 1:435
enkephalinamide-
Leu, Ala(2)-
aminoethyl dimer
82221-89-4
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Life Sci 1982;31(15):1625
enkephalinamide-
Leu, de-
Tyr(1)-
Ala(2)
84145-88-0 L-
Leucinamide, D-
alanylglycyl-
L-
phenylalanyl
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Biochem Pharmacol 1982;31(16):2699
enkephalinamide-
Leu, Ala(2)
65189-64-2 L-
leucinamide, L-
tyrosyl-
D-
alanylglycyl-
L-
phenylalanyl
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Neurochem Res 1981;6(3):321
azoenkephalin
76995-89-6 L-
Leucine, glycylglycyl-
4-
((5-
(2-
amino-
2-
carboxyethyl)-
2-
hydroxyphenyl)azo)-
L-
phenylalanyl-
, cyclic (3-
1)-
peptide
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Mol Cell Biochem 1981;34(1):23
2-
Ala-
5-
N-
Et-
Leu-
enkephalinamide
67787-85-3 L-
tyrosyl-
D-
alanylglycyl-
L-
phenylalanyl-
N-
ethyl-
D-
leucinamide
Enkephalin, Leucine-2-Alanine/*analogs & derivatives.
Br J Pharmacol 1980;68(1):159P