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Quisqualic Acid

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Definition: An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis.     
Pharmacological Action Excitatory Amino Acid Agonists 		Other names Quisqualate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-amino-3-(2'-(3',5'-dioxo-1',2',4'-oxadiazolidinyl))cyclobutane-1-carboxylic acid  0   Quisqualic Acid/*analogs & derivatives Ligands. J Med Chem 1999 May 6;42(9):1639-47
methylquisqualic acid  0   Quisqualic Acid/*analogs & derivatives. Bioorg Med Chem Lett 1998 Mar 3;8(5);447-52
benzylquisqualic acid  0   Quisqualic Acid/*analogs & derivatives. Bioorg Med Chem Lett 1998 Mar 3;8(5);447-52
homoquisqualic acid  0   Quisqualic Acid/*analogs & derivatives. Br J Pharmacol 1998 Jan;123(2):269-74
homoquisqualamine  158923-63-8 1,2,4-Oxadiazolidine-3,5-dione, 2-(3-aminopropyl)  Quisqualic Acid/*analogs & derivatives. Rev Esp Fisiol 1994 Mar;50(1):11-8
quisqualamine  68373-11-5   Quisqualic Acid/*analogs & derivatives. J Pharm Pharmacol 30(6):364;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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