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Boron Neutron Capture Therapy

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Definition: A technique for the treatment of neoplasms, especially gliomas and melanomas in which boron-10, an isotope, is introduced into the target cells followed by irradiation with thermal neutrons.  do not use /util except by MeSH definition; coord IM with disease /radiother (IM); DF: BNCT    Other names Therapy, Boron-Neutron Capture; Therapy, Boron Neutron Capture; Neutron Capture Therapy, Boron; Boron-Neutron Capture Therapy
 
SubstanceCAS Registry & nameCategoriesSource
3-((closo-o-carboran-1-yl)methyl)thymidine  0   *Boron Compounds Thymidine/*analogs & derivatives Boron Neutron Capture Therapy. J Med Chem 2005 Feb 24;48(4):1188-98
3-(3-(7-ammonium-nido-m-carboran-1-yl)propan-1-yl)thymidine  0   *Boron Compounds Thymidine/*analogs & derivatives Boron Neutron Capture Therapy. J Med Chem 2005 Feb 24;48(4):1188-98
TX-2060  0   *Borohydrides *Nitroimidazoles *Sulfhydryl Compounds Boron Neutron Capture Therapy. Anticancer Res 2004 Sep-Oct;24(5A):2975-83
4-dihydroxyborylphenylalanine  0   *Boron Compounds Phenylalanine/*analogs & derivatives Boron Neutron Capture Therapy. Clin Chem 2001 Oct;47(10):1796-803
borotrimethylglycylphenylalanine  0   *Boron Compounds Alanine/*analogs & derivatives Boron Neutron Capture Therapy. Radiat Res 2001 Jul;156(1):118-22
STA BX909  0   *Metalloporphyrins Boron Compounds Boron Neutron Capture Therapy. Cancer Lett 1999 Jul 1;141(1-2):203-9
((4-(B-hydroxyboryl)phenyl)methyl)spermidine  0   *Boron Compounds Spermidine/*analogs & derivatives Boron Neutron Capture Therapy. J Med Chem 1999 Apr 8;42(7):1282-92
N(5)-(4-(2-aminoethyl-2-carboranyl)butyl)spermidine  0   *Boron Compounds Spermidine/*analogs & derivatives Boron Neutron Capture Therapy. J Med Chem 1999 Apr 8;42(7):1282-92
imidocaptate  0   *Boron Compounds *Nitroimidazoles Boron Neutron Capture Therapy. J Med Chem 1996 Mar 29;39(7):1540-4
1-(9-o-carboranyl)nonyl-2-methyl-glycero-3-phosphocholine  0   *Boranes *Phosphatidylcholines Boron Neutron Capture Therapy. Anticancer Drugs 1994 Feb;5(1):43-52
ANC 1  156341-52-5   *Boranes *Propylamines Boron Neutron Capture Therapy. Anticancer Drugs 1994 Feb;5(1):43-52
DAC 1  156341-53-6 1,3-Propanediol, 2-((2-(3-aminopropyl)-1,2-dicarbadodecaboran(12)-1-yl)methoxy)  *Boranes Boron Neutron Capture Therapy. Anticancer Drugs 1994 Feb;5(1):43-52
2,4-(alpha,beta-dihydroxyethyl)deuteroporphyrin IX tetrakiscarborane carboxylate ester  0   *Boron Compounds *Deuteroporphyrins Boron Neutron Capture Therapy. J Magn Reson Imaging 1993 Mar-Apr;3(2):351-6
mercaptoundecahydrododecaborate  12294-22-3   *Borohydrides *Sulfhydryl Compounds Boron Neutron Capture Therapy. Chem Pharm Bull 24(12):2934;1976; Invest Ophthalmol Vis Sci 16(7):654;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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