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Acid Anhydride Hydrolases

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Definition: A group of enzymes that catalyze the hydrolysis of diphosphate bonds in compounds such as nucleoside di- and tri-phosphates, and sulfonyl-containing anhydrides such as adenylylsulfate. (Enzyme Nomenclature, 1992) EC 3.6.     
Examples Adenosine Triphosphatases; Apyrase; GTP Phosphohydrolases; Nucleoside-Triphosphatase; Pyrophosphatases; Thiamin-Triphosphatase 		Other names Hydrolases, Acid Anhydride; Anhydride Hydrolases, Acid
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
HIT-45 protein, Trypanosoma brucei  EC 3.6.1.29   *Protozoan Proteins *Acid Anhydride Hydrolases. RNA. 2009 Aug;15(8):1554-64
RppH protein, E coli  EC 3.6.1.-   *Acid Anhydride Hydrolases *Escherichia coli Proteins. Nature 2008 Jan 17;451(7176):355-8
histidine triad protein, E coli  EC 3.6.1.-   *Acid Anhydride Hydrolases *Escherichia coli Proteins. Biochemistry 2007 Nov 13;46(45):13074-9
Ppx protein, Escherichia coli  EC 3.6.1.11   *Bacterial Proteins *Acid Anhydride Hydrolases. Structure. 2006 Aug;14(8):1263-72
MIG-23 protein, C elegans  EC 3.6.1.6   *Acid Anhydride Hydrolases *Caenorhabditis elegans Proteins. Nat Cell Biol. 2004 Jan;6(1):31-7
AcPDro2 protein, Drosophila  EC 3.6.1.7   *Acid Anhydride Hydrolases *Drosophila Proteins. FEBS Lett 2003 Jan 30;535(1-3):171-4
T-VD146 protein, Amblyomma hebraeum  EC 3.6.1.-   *Acid Anhydride Hydrolases. Insect Biochem Mol Biol 2002 Jul;32(7):785-93
T-VD16 protein, Amblyomma hebraeum  EC 3.6.1.-   *Acid Anhydride Hydrolases. Insect Biochem Mol Biol 2002 Jul;32(7):785-93
DIPP2 protein, rat  EC 3.6.1.-   *Acid Anhydride Hydrolases. Neuropsychopharmacology 2001 Jun;24(6):640-51
NudH protein, Bartonella bacilliformis  EC 3.6.1.-   *Bacterial Proteins *Acid Anhydride Hydrolases. J Biol Chem 1999 Jan 15;274(3):1203-6
mRNA capping enzyme, Kluyveromyces lactis  EC 2.7.7.-   *Methyltransferases *Nucleotidyltransferases *Acid Anhydride Hydrolases. Plasmid 1998 Nov;40(3):243-6
diphosphoinositol polyphosphate phosphohydrolase  EC 3.6.1.-   *Acid Anhydride Hydrolases. EMBO J 1998 Nov 16;17(22):6599-607
Orf163w protein, S cerevisiae  EC 3.6.1.-   *Acid Anhydride Hydrolases *Saccharomyces cerevisiae Proteins. Biochem Soc Trans 1997 Nov;25(4):S580
adenosine tetraphosphatase  EC 3.6.1.14   *Acid Anhydride Hydrolases. Biochem J 1997 Nov 15;328( Pt 1):257-62
CEL-1 protein, C elegans  EC 3.1.3.33   *Nucleotidyltransferases *Acid Anhydride Hydrolases *Caenorhabditis elegans Proteins. Cell 1997 Jun 13;89(6):867-73
fragile histidine triad protein  0   *Neoplasm Proteins *Acid Anhydride Hydrolases Genes, Tumor Suppressor. Biochem Biophys Res Commun 1983;115(1):253; Cell 1996 Feb 23;84(4):587-97
diadenosine polyphosphate hydrolase  EC 3.6.1.-   *Acid Anhydride Hydrolases. Arch Biochem Biophys 1992 Aug 15;297(1):176-83
bis(5'-nucleosyl)tetraphosphatase (symmetrical)  EC 3.6.1.41   *Acid Anhydride Hydrolases. Biochemistry 1982;21(24):6123
beta-(2-furyl)-acryloyl phosphate hydrolase  EC 3.6.1.-   *Acid Anhydride Hydrolases. Biochem Biophys Res Commun 1981;101(3):775
nucleoside-diphosphatase  EC 3.6.1.6   *Acid Anhydride Hydrolases. Acta Histochem (Jena) 1979;65(2):138; Biochem Biophys Res Commun 82(3):913;1978; Biochem J 169(2):297;1978; Biochem J 177(3):925;1979; Biochemistry 17(17):3546;1978; Biochim Biophys Acta 525(1):265;1978; Can J Biochem 56(6):565;1978; J Anat 1980;130(1):173; J Bacteriol 1980;141(2):948; J Helminthol 1979;53(3):261
tripolyphosphatase  EC 3.6.1.-   *Acid Anhydride Hydrolases. Biokhimiia 41(11):1958;1976; Biokhimiia 43(10):1790;1978; Z Lebensm Unters Forsch 164:34;1977
RNA triphosphatase  EC 3.6.1.-   *Acid Anhydride Hydrolases. J Biol Chem 255(3):903;1980
trimetaphosphatase  EC 3.6.1.2   *Acid Anhydride Hydrolases. J Histochem Cytochem 1980;28(2):183; J Histochem Cytochem 28(1):78;1980
endopolyphosphatase  EC 3.6.1.10   *Acid Anhydride Hydrolases. Biokhimiia 42(6):1083;1977; Biokhimiia 44(4):715;1979
nucleoside phosphoacylhydrolase  EC 3.6.1.24   *Acid Anhydride Hydrolases. Eur J Biochem 12(2):270;1970
inosine diphosphatase  EC 3.6.1.-   *Acid Anhydride Hydrolases. Acta Histochem 15(suppl):177;1975; Am J Clin Nutr 30(8):1359;1977; Arch Pathol Lab Med 102(2):90;1978; Biol Reprod 11(5):601;1974; Eur J Cell Biol 1980;20(3): 228; Int J Parasit 3(1):59;1973; J Biol Chem 251(24):7821;1976
exopolyphosphatase  EC 3.6.1.11   *Acid Anhydride Hydrolases. Biochim Biophys Acta 321(1):336;1973
bis(5'-adenosyl)triphosphatase  EC 3.6.1.29   *Acid Anhydride Hydrolases. Eur J Biochem 76:331;1977
bis(5'-nucleosyl)tetraphosphatase (asymmetrical)  EC 3.6.1.17   *Acid Anhydride Hydrolases. Biochim Biophys Acta 358(1):117;1974
acylphosphatase  EC 3.6.1.7   *Acid Anhydride Hydrolases. Clin Chim Acta 40(1):262;1972; Int J Pept Protein Res 1979;14(3):227; Physiol Chem Phys 10(2):153;1978; Physiol Chem Phys 10(4):367;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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