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Receptors, Tachykinin

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Definition: Cell surface proteins that bind tachykinins with high affinity and trigger intracellular changes influencing the behavior of cells. Three classes of tachykinin receptors have been characterized, the NK-1; NK-2; and NK-3; which prefer, respectively, substance P, neurokinin A (substance K, neurokinin alpha, neuromedin L), and neurokinin B (neurokinin beta, neuromedin K).  DF: RECEPT TACHYKININ   
Examples Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3 		Other names Tachykinin Receptors; Tachykinins Receptors; Receptor, Tachykinin; Tachykinin Receptor; Receptors, Tachykinins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6-methylbenzo(b)thiophene-2-carboxylic acid (1-(2-phenyl-((1-(tetrahydropyran-4-ylmethyl)piperidin-4-ylmethyl)carbamoyl)ethylcarbamoyl)cyclophenyl)amide  0   *Dipeptides *Thiophenes Receptors, Tachykinin/antagonists & inhibitors. Eur J Pharmacol 2006 Nov 7;549(1-3):140-8
Klre1 protein, mouse  0   *Receptors, Tachykinin. Blood 2004 Aug 1;104(3);781-3
ZD 6021  0   *Piperidines *Sulfoxides Receptors, Tachykinin/antagonists & inhibitors. J Pharmacol Exp Ther 2001 Jul;298(1):307-15
CGP 55000  0   *Piperidines *Quinolines Receptors, Tachykinin/antagonists & inhibitors. Biol Chem 1999 Nov;380(11):173-81
TAK 637  0   *Naphthyridines Receptors, Tachykinin/antagonists & inhibitors. Eur J Pharmacol 1999 Nov 3;383(3):297-303
MEN 11467  0   *Cyclohexylamines *Indoles Receptors, Tachykinin/antagonists & inhibitors. Eur J Pharmacol 1999 Jun 25;374(3):435-43
MEN 10581  0   *Peptides, Cyclic Receptors, Tachykinin/antagonists & inhibitors. Br J Pharmacol 1999 Jan;126(1):131-6
R 820  0   *Indoles *Oligopeptides Receptors, Tachykinin/antagonists & inhibitors Receptors, Neurokinin-3/antagonists & inhibitors. Br J Pharmacol 1997 Oct;122(4):643-54
R 486  0   *Oligopeptides Receptors, Tachykinin/antagonists & inhibitors. Br J Pharmacol 1997 Oct;122(4):643-54
MEN 11420  0   *Peptides, Cyclic Receptors, Tachykinin/antagonists & inhibitors.
Pharma Action Bronchodilator Agents 		Naunyn Schmiedebergs Arch Pharmacol 1997 Aug;356(2):182-8
STKR receptor, Stomoxys calcitrans  0   *Receptors, Invertebrate Peptide *Receptors, Tachykinin *Insect Proteins GTP-Binding Proteins. Peptides 1997;18(1):1-5
neurokinin receptor 4  0   *Receptors, Tachykinin. Biochem J 1996 Nov 15;320(Pt 1):1-5
Takr86C protein, Drosophila  0   *Receptors, Tachykinin *Drosophila Proteins. J Biol Chem 1992;267(2):1298
eledoisin receptor  0   *Receptors, Tachykinin. Science 1984;226(4677):987

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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