Definition: A major cytochrome P-450 enzyme which is inducible by PHENOBARBITAL in both the LIVER and SMALL INTESTINE. It is active in the metabolism of compounds like pentoxyresorufin, TESTOSTERONE, and ANDROSTENEDIONE. This enzyme, encoded by CYP2B1 gene, also mediates the activation of CYCLOPHOSPHAMIDE and IFOSFAMIDE to MUTAGENS.
do not confuse with other cytochrome P-450 CYP's
Other names Pentoxyresorufin O Dealkylase; O-Dealkylase, Pentoxyresorufin; Cytochrome P 450 CYP2B1; Benzyloxyresorufin O Dealkylase; 7 Pentylresorufin O Depentylase; 7 Benzyloxyresorufin O Dealkylase; Cytochrome P450 2B1; CYP 2B1; 7-Pentylresorufin O-Depentylase; 7-Benzyloxyresorufin O-Dealkylase; Pentoxyresorufin O-Dealkylase; PROD; CYP2B1; Benzyloxyresorufin O-Dealkylase; BROD
