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Cytochrome P-450 CYP2E1

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Definition: An ethanol-inducible cytochrome P450 enzyme that metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Substrates include alcohol; NITROSAMINES; BENZENE; URETHANE; and other low molecular weight compounds. CYP2E1 has been used as an enzyme marker in the study of alcohol abuse.  do not confuse with other cytochrome P-450 CYP's    Other names N Nitrosodimethylamine Demethylase; Dimethylnitrosamine N Demethylase; Cytochrome P 450 J; Cytochrome P 450 IIE1; Cytochrome P 450 CYP2E1; 4 Nitrophenol 2 Hydroxylase; N-Nitrosodimethylamine Demethylase; Cytochrome P450 2E1; Cytochrome P-450-J; Cytochrome P-450 IIE1; Cytochrome P-450 (ALC); CYPIIE1; CYP IIE1; CYP 2E1; Dimethylnitrosamine N-Demethylase; CYP2E1; 4-Nitrophenol-2-Hydroxylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(allylthio)pyrazine  0   *Pyrazines Cytochrome P-450 CYP2E1/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Biochem Pharmacol 1997 Feb 7;53(3):261-9

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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