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Amide Synthases

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Definition: Enzymes that catalyze the joining of either ammonia or an amide with another molecule, in which the linkage is in the form of a carbon-nitrogen bond. EC 6.3.1.     
Examples Aspartate-Ammonia Ligase; Glutamate-Ammonia Ligase 		Other names Synthases, Amide; Ligases, Acid-Ammonia; Ligases, Acid-Amide; Acid Ammonia Ligases; Acid Amide Ligases; Acid-Ammonia Ligases; Acid-Amide Ligases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
theanine synthetase  EC 6.3.1.6   *Amide Synthases. J Chromatogr B Analyt Technol Biomed Life Sci 2005 May 5;819(1):81-4
Qns1 protein, S cerevisiae  EC 6.3.1.5   *Amide Synthases. J Biol Chem 2003 Aug 29;278(35):33049-55
glutamine synthetase-like protein, human  EC 6.3.1.-   *Nerve Tissue Proteins *Amide Synthases. J Neurochem 2000 Dec;75(6):2574-82
Cfl protein, Pseudomonas syringae  EC 6.3.1.-   *Bacterial Proteins *Amide Synthases. Gene 1995 Feb 3;153(1):17-23
glutathionylspermidine synthetase  EC 6.3.1.8   *Amide Synthases. Protein Sci 1992 Jul;1(7):874-83
trypanothione synthetase  EC 6.3.1.9   *Amide Synthases. Biochemistry 1990;29(16):3924
NAD+ synthase  EC 6.3.1.5   *Amide Synthases. J Bacteriol 1983;155(1):213
4-methyleneglutamine synthetase  EC 6.3.1.7   *Amide Synthases. Biochem Biophys Res Commun 1983;111(2):484
pteroylpolyglutamate synthase  EC 6.3.1.-   *Amide Synthases. Methods Enzymol 1980;66:630
novobiocic acid synthetase  EC 6.3.1.-   *Amide Synthases. Methods Enzymol 43:502;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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