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Carbon-Carbon Lyases

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Definition: Enzymes that catalyze the cleavage of a carbon-carbon bond by means other than hydrolysis or oxidation. This subclass contains the DECARBOXYLASES, the ALDEHYDE-LYASES, and the OXO-ACID-LYASES. EC 4.1.  DF: C C LYASES   
Examples Aldehyde-Lyases; Carboxy-Lyases; Deoxyribodipyrimidine Photo-Lyase; Oxo-Acid-Lyases; Tryptophanase; Tyrosine Phenol-Lyase
Other names Lyases, Carbon-Carbon; Carbon Carbon Lyases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
R-citramalyl-coenzyme A lyase, Chloroflexus aurantiacus  EC 4.1.-   *Carbon-Carbon Lyases. J Bacteriol 2007 Apr;189(7):2906-14
stemodene synthase, Oryza sativa  EC 4.1.-   *Carbon-Carbon Lyases. Arch Biochem Biophys 2006 Apr 15;448(1-2):133-40
stemar-13-ene synthase  EC 4.1.-   *Carbon-Carbon Lyases. FEBS Lett 2004 Jul 30;571(1-3):182-6
phenylphosphate carboxylase, Thauera aromatica  EC 4.1.-   *Carbon-Carbon Lyases. J Bacteriol 2004 Jul;186(14):4556-67
carboxymethylproline synthase  EC 4.1.-   *Carbon-Carbon Lyases. J Biol Chem 2004 Feb 20;279(8):6730-6
4-hydroxybenzaldehyde synthase, Vanilla planifolia  EC 4.1.99.-   *Carbon-Carbon Lyases. Phytochemistry 2002 Nov;61(6):611-20
citral lyase  EC 4.1.2.-   *Carbon-Carbon Lyases. Appl Microbiol Biotechnol 2001 Dec;57(5-6):731-7
methylisocitrate lyase  EC 4.1.3.30   *Carbon-Carbon Lyases Saccharomyces cerevisiae Proteins. J Bacteriol 2000 Dec;182(24):7007-13
8-epicedrol synthase  EC 4.1.99.-   *Carbon-Carbon Lyases. Arch Biochem Biophys 1999 Sep 15;369(2):213-22
2-hydroxyphytanoyl-coenzyme A lyase  EC 4.1.99.-   *Carbon-Carbon Lyases. Proc Natl Acad Sci U S A 1999 Aug 31;96(18):10039-44
benzylsuccinate synthase  EC 4.1.99.-   *Carbon-Carbon Lyases. Mol Microbiol 1998 May;28(3):615-28
UVR3 protein, Arabidopsis  EC 4.1.99.-   *Carbon-Carbon Lyases *Arabidopsis Proteins. Nucleic Acids Res 1998 Jan 15;26(2):638-44
MosA protein, Rhizobium meliloti  EC 2.1.1.-   *Bacterial Proteins *Carbon-Carbon Lyases. J Bacteriol 1993 Aug;175(16):5193-204
PabA protein, E coli  EC 4.1.3.-   *Carbon-Carbon Lyases *Escherichia coli Proteins. Biochemistry 1992 Aug 4;31(30):6904-10
o-succinylbenzoic acid synthase  EC 4.1.99.-   *Carbon-Carbon Lyases. Arch Biochem Biophys 1987;256(1):212
trichodiene synthetase  EC 4.2.3.6   *Carbon-Carbon Lyases. Arch Biochem Biophys 1986;251(2):756
(1-hydroxycyclohexan-1-yl)acetyl-CoA lyase  EC 4.1.99.-   *Carbon-Carbon Lyases. J Bacteriol 1982;150(3):1177
1-aminocyclopropane-1-carboxylate deaminase  EC 4.1.99.4   *Carbon-Carbon Lyases. Biochemistry 1981;20(26):7509
1,8-cineole synthetase  EC 4.1.-   *Carbon-Carbon Lyases. Arch Biochem Biophys 179(1):257;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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