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Carboxy-Lyases

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Definition: Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.     
Examples Adenosylmethionine Decarboxylase; Aromatic-L-Amino-Acid Decarboxylases; Glutamate Decarboxylase; Histidine Decarboxylase; Indole-3-Glycerol-Phosphate Synthase; Methylmalonyl-CoA Decarboxylase; Ornithine Decarboxylase; Orotidine-5'-Phosphate Decarboxylase; Phosphoenolpyruvate Carboxykinase (ATP); Phosphoenolpyruvate Carboxykinase (GTP); Phosphoenolpyruvate Carboxylase; Pyruvate Decarboxylase; Ribulose-Bisphosphate Carboxylase; Tyrosine Decarboxylase; Uroporphyrinogen Decarboxylase 		Other names Decarboxylases; Carboxy Lyases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ALKBH4 protein, human  EC 4.1.1.-   *Carboxy-Lyases. Biochem J 2011 Feb 24;434(3):391-8
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, Klebsiella pneumoniae  EC 4.1.1.-   *Bacterial Proteins *Carboxy-Lyases. J Biol Chem 2010 Nov 12;285(46):35446-54
U4kpxs protein, Ralstonia solanacearum  0   *Alcohol Oxidoreductases *Carboxy-Lyases *Multienzyme Complexes. J Biol Chem 2010 Mar 19;285(12):9030-40
ADC protein, human  EC 4.1.1.19   *Carboxy-Lyases Enzyme Inhibitors. PLoS One. 2009;4(8) (dup#10):e6858
paics protein, zebrafish  0   *Carboxy-Lyases *Peptide Synthases *Zebrafish Proteins. Development. 2009 Aug;136(15); 2601-11
parafibromin protein, Drosophila  EC 4.1.1.-   *Carboxy-Lyases *Drosophila Proteins. Mech Dev 2009 May-Jun;126(5-6):394-405
Malonic aciduria  0   *Metabolism, Inborn Errors Carboxy-Lyases/deficiency Methylmalonic Acid.
Ade5 protein, Candida albicans  EC 4.1.1.21   *Carboxy-Lyases *Peptide Synthases. Microbiology 2007 Jul;153(Pt 7):2351-62
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase, Arabidopsis  EC 4.1.1.-   *Carboxy-Lyases *Arabidopsis Proteins. J Biol Chem 2007 Aug 10;282(32):23457-64
2-oxo-4-hdyroxy-4-carboxy-5-ureidoimidazoline decarboxylase, zebrafish  EC 4.1.1.-   *Carboxy-Lyases *Zebrafish Proteins. J Biol Chem 2007 Jun 22;282(25):18182-9
2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline decarboxylase, mouse  EC 4.1.1.-   *Carboxy-Lyases. Nat Chem Biol 2006 Mar;2(3):144-8
Dfp protein, E coli  0   *Carboxy-Lyases *Multienzyme Complexes *Peptide Synthases *Escherichia coli Proteins.
gamma-resorcylic acid decarboxylase, Rhizobium radiobacter  EC 4.1.1.-   *Carboxy-Lyases. Biochem Biophys Res Commun 2004 Nov 12;324(2):611-20
LysA protein, Mycobacterium tuberculosis  EC 4.1.1.20   *Bacterial Proteins *Carboxy-Lyases.
LysA protein, E coli  EC 4.1.1.20   *Carboxy-Lyases *Escherichia coli Proteins.
2,6-dihydroxybenzoate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. Arch Microbiol 2004 Jun;181(6):391-7
L-3,4-dihydroxyphenylalanine decarboxylase, Bombyx mori  EC 4.1.1.-   *Carboxy-Lyases. Biotechnol Lett 2003 Jun;25(12):997-1002
yellow f2 protein, Drosophila  0   *Carboxy-Lyases *Isomerases *Multienzyme Complexes Drosophila Proteins. Biochem J 2002 Nov;368(Pt 1):333-40
yellow f protein, Drosophila  0   *Carboxy-Lyases *Isomerases *Multienzyme Complexes Drosophila Proteins. Biochem J 2002 Nov;368(Pt 1):333-40
SQV-1 protein, C elegans  EC 4.1.1.35   *Carboxy-Lyases *Caenorhabditis elegans Proteins Membrane Proteins. Proc Natl Acad Sci U S A 2002 Oct 29;99(22):14218-23
5-carboxyvanillate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. Appl Environ Microbiol 2002 Sep;68(9):4407-15
4-hydroxycinnamate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. Biosci Biotechnol Biochem 2001 Dec;65(12):2604-12
3-keto-L-gulonate 6-phosphate decarboxylase, E coli  EC 4.1.1.-   *Carboxy-Lyases *Escherichia coli Proteins. Biochemistry 2002 Mar 26;41(12):3861-9
MrsD protein, Bacillus  EC 4.1.1.-   *Bacterial Proteins *Carboxy-Lyases *Flavoproteins. J Bacteriol 2002 Mar;184(5):1234-43
indolepyruvate - methylviologen oxidoreductase  0   *Carboxy-Lyases *Multienzyme Complexes *Oxidoreductases. FEBS Lett 2002 Jan 16;510(3):196-200
L-serine decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. J Biol Chem 2001 Sep 21;276(38):35523-9
4-hydroxyphenylacetate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. Eur J Biochem 2001 Mar;268(5):1363-72
phenolic acid decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. J Bacteriol 2000 Dec;182(23):6724-31
precarthamin decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. Arch Biochem Biopys 2000 Oct 15;382(2):238-44
3-octaprenyl-4-hydroxybenzoate carboxy-lyase  EC 4.1.1.-   *Carboxy-Lyases. J Bacteriol 2000 Nov;182(21):6243-6
S-methylmethionine decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. Plant Physiol 2000 Jul;123(3):1153-61
sulfopyruvate decarboxylase, Methanococcus jannaschii  EC 4.1.1.-   *Carboxy-Lyases *Archaeal Proteins. J Bacteriol 2000 Sep;182(17):4862-7
ade5 protein, Drosophila  EC 4.1.1.21   *Carboxy-Lyases *Peptide Synthases *Drosophila Proteins. Genetics 2000 Mar;154(3):1239-53
polyprenyl-4-hydroxybenzoate carboxylase  EC 4.1.1.-   *Carboxy-Lyases. J Bacteriol 1980;143(2):644
4alpha-carboxysterol-C3 dehydrogenase  EC 4.1.1.-   *Carboxy-Lyases. Arch Biochem Biophys 1999 Jun 15;366(2):249-60
isoorotate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. Anal Biochem 1999 Jan 1;266(1):85-92
MadF protein, Malonomonase rubra  0   *Biotin *Bacterial Proteins *Carboxy-Lyases. Arch Microbiol 1998 Nov;170(6):464-8
PPD protein, Streptomyces viridochromogenes  EC 4.1.1.-   *Bacterial Proteins *Carboxy-Lyases. FEMS Microbiol Lett 1998 Jun 15;163(2):149-57
ubiX protein, E coli  EC 4.1.1.-   *Carboxy-Lyases *Escherichia coli Proteins. J Bacteriol 1998 Jul;180(14):3681-5
pyrrole-2-carboxylate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. Eur J Biochem 1998 Apr 15;253(2):480-4
threonine-O-3-phosphate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. J Biol Chem 1998 Jan 30;273(5):2684-91
epoxide carboxylase  EC 4.1.1.-   *Carboxy-Lyases. J Biol Chem 1997 Dec 19;272(51):32121-8
phenylpyruvate decarboxylase  EC 4.1.1.43   *Carboxy-Lyases. Arch Microbiol 1997 Oct;168(4):310-20
2,4-diaminobutyrate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. Arch Microbiol 1996 Aug;166(2):128-31
acetone carboxylase  EC 4.1.1.-   *Carboxy-Lyases. J Bacteriol 1996 Jul;178(14):4020-6
3,4-dihydroxybenzoate decarboxylase  EC 4.1.1.63   *Carboxy-Lyases. J Bacteriol 1996 Jun;178(12):3539-43
2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. J Bacteriol 1996 Mar;178(5):1351-62
pyr4 protein, Rhizopus  EC 4.1.1.23   *Carboxy-Lyases *Fungal Proteins. Curr Genet 1995 Apr;27(5):472-8
carboxynorspermidine decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. Microbiology 1994 Nov;140(Pt 11):3117-24
phenylacrylic acid decarboxylase  EC 4.1.1.-   *Carboxy-Lyases Saccharomyces cerevisiae Proteins. Gene 1994 May 3;142(1):107-12
LysA protein, Bacteria  EC 4.1.1.20   *Bacterial Proteins *Carboxy-Lyases. Gene 1993 Feb 14;124(1):105-9
epidermin decarboxylase  EC 1.3.99.-   *Carboxy-Lyases *Oxidoreductases Bacteriocins. J Bacteriol 1992 Aug;174(16):5354-61
purK protein, E coli  EC 4.1.1.21   *Carboxy-Lyases *Escherichia coli Proteins. Biochemistry 1992 Jun 2;31(21):5022-32
L-tartrate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. J Biochem (Tokyo) 1991 Oct;110(4):520-5
malonate decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. J Gen Microbiol 1991;137(Pt 8):2025
malonate semialdehyde decarboxylase  EC 4.1.1.-   *Carboxy-Lyases. J Gen Microbiol 1991;137(Pt 8):2025
indolepyruvate decarboxylase  EC 4.1.1-   *Carboxy-Lyases. Mol Gen Genet 1991;226(1-2):10
methionine decarboxylase  EC 4.1.1.57   *Carboxy-Lyases. Biochemistry 1990;26(33):7631
4-hydroxybenzoate decarboxylase  EC 4.1.1.61   *Carboxy-Lyases. J Bacteriol 1990;172(10):5901
2,2-dialkylglycine decarboxylase  EC 4.1.1.64   *Carboxy-Lyases. J Biol Chem 1990;265(10):5531
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