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Peptide Synthases
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Definition
: Ligases that catalyze the joining of adjacent AMINO ACIDS by the formation of carbon-nitrogen bonds between their carboxylic acid groups and amine groups.
Examples
Glutamate-Cysteine Ligase
;
Glutathione Synthase
Other names
Peptide Synthetases; Synthetases, Peptide; Synthases, Peptide; Ligases, Acid-
Amino-
Acid; Acid Amino Acid Ligases; Acid-
Amino-
Acid Ligases
Substance
CAS Registry & name
Categories
Source
Drugs
*
MurE protein, Mycobacterium tuberculosis
EC 6.3.2.13
*Bacterial Proteins
*Peptide Synthases.
J Antimicrob Chemother. 2010 Oct;65(10):2101-7
TTLL12 protein, human
EC 6.3.2.-
*Peptide Synthases.
Int J Cancer 2010 Dec 1;127(11):2542-53
paics protein, zebrafish
0
*Carboxy-Lyases
*Peptide Synthases
*Zebrafish Proteins.
Development. 2009 Aug;136(15); 2601-11
Ttll3 protein, zebrafish
EC 6.3.2.-
*Peptide Synthases
*Zebrafish Proteins.
Dev Cell 2009 Jun;16(6):867-76
epsilon-
poly-
L-
lysine synthethase, Streptomyces albulus
EC 6.3.2.-
*Peptide Synthases.
Nat Chem Biol 2008 Dec;4(12):766-72
Ade5 protein, Candida albicans
EC 4.1.1.21
*Carboxy-Lyases
*Peptide Synthases.
Microbiology 2007 Jul;153(Pt 7):2351-62
Atg3 protein, rat
EC 6.3.2.-
*Peptide Synthases.
Mol Vis 2006;12:1292-302
Pes1 protein, Aspergillus fumigatus
EC 6.3.2.
*Fungal Proteins
*Peptide Synthases.
FEBS 2006 Jul;273(13):3038-53
TTLL6 protein, human
EC 6.3.2.-
*Peptide Synthases.
Gene 2006 Mar 29;370:58-63
folC protein, E coli
EC 6.3.2.-
*Multienzyme Complexes
*Peptide Synthases
*Escherichia coli Proteins.
Dfp protein, E coli
0
*Carboxy-Lyases
*Multienzyme Complexes
*Peptide Synthases
*Escherichia coli Proteins.
3,4-
dihydroxy-
2-
butanone 4-
phosphate synthase, C albicans
EC 6.3.2.
*Peptide Synthases.
J Mol Biol. 2004 Aug 20;341(4):1085-96
arthrofactin synthetase
EC 6.3.2.-
*Peptide Synthases.
Chem Biol 2003 Sep;10(9):869-80
FemX UDP-
MurNAc-
pentapeptide l-
alanine ligase
EC 6.3.2.-
*Peptide Synthases.
Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1055-7
penicillin-
binding protein 2a, Streptococcus
0
*Peptide Synthases
*Penicillin-Binding Proteins.
IndC protein, Erwinia chrysanthemi
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
J Bacteriol 2002 Feb;184(3):654-65
gamma-
polyglutamic acid synthetase
EC 6.3.2.-
*Peptide Synthases.
J Bacteriol 2002 Jan;184(2):337-43
Psy1 protein, Trichoderma virens
EC 6.3.2.-
*Fungal Proteins
*Peptide Synthases.
Appl Environ Microbiol 2001 Nov;67(11):5055-62
microcystin synthetase A
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases
Microcystins.
Appl Environ Microbiol 2001 Jun;67(6):2810-8
Sid2 protein, Ustilago maydis
EC 6.3.2.-
*Fungal Proteins
*Peptide Synthases.
J Bacteriol 2001 Jul;183(13):4040-51
AM-
toxin synthetase
EC 6.3.2.-
*Peptide Synthases.
Mol Plant Microbe Interact 2000 Jul;13(7):742-53
PFSYN depsipeptide synthetase
EC 6.3.2.-
*Peptide Synthases
Depsipeptides.
J Biol Chem 2000 Jun 9;275(23):17909-15
ade5 protein, Drosophila
EC 4.1.1.21
*Carboxy-Lyases
*Peptide Synthases
*Drosophila Proteins.
Genetics 2000 Mar;154(3):1239-53
MurN protein, Streptococcus pneumoniae
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4891-6
MurM protein, Streptococcus pneumoniae
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4891-6
VibF protein, bacteria
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
J Bacteriol 2000 Mar;182(6):1731-8
MbtB protein, Mycobacterium tuberculosis
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
Chem Biol 1998 Nov;5(11):631-45
homoglutathione synthase
EC 6.3.2.23
*Peptide Synthases.
Plant Physiol 1999 Nov;121(3):753-61
aryl-
4,2-
bisthiazoline synthetase, Pseudomonas aeruginosa
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
Biochemistry 1999 Nov 9;38(45):14941-54
VanD protein, Enterococcus faecium
EC 6.3.2.4
*Bacterial Proteins
*Peptide Synthases.
J Infect Dis 1999 Oct;180(4):1177-85
subtiligase
EC 6.3.2.-
*Peptide Synthases
*Subtilisins.
Biochem Biophys Res Commun 1999 Jan 8;254(1):147-51
FxbB protein, Mycobacterium smegmatis
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
Mol Microbiol 1998 Jul;29(2):629-39
FxbC protein, Mycobacterium smegmatis
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
Mol Microbiol 1998 Jul;29(2):629-39
cyanophycin synthase, bacteria
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
Eur J Biochem 1998 May 15;254(1):154-9
tubulin polyglutamylase
EC 6.3.2.-
*Peptide Synthases
Polyglutamic Acid
Tubulin.
Biochemistry 1998 Jun 9;37(23):8395-404
fengycin synthetase
EC 6.3.2.-
*Peptide Synthases.
J Bacteriol 1998 Mar;180(5):1338-41
VanC protein, Enterococcus
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases
Drug Resistance, Microbial.
Proc Natl Acad Sci U S A 1997 Sep 16;94(19):10040-4
APS protein, Amycolatopsis mediterranei
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
J Biotechnol 1997 Aug 11;56(2):115-28
pipecolate-
incorporating enzyme, Streptomyces
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
Eur J Biochem 1997 Jul 15;247(2):526-34
lysergyl peptide synthetase
EC 6.3.2.-
*Peptide Synthases.
J Biol Chem 1996 Nov 1;271(44):27524-30
non-
ribosomal peptide synthase
EC 6.3.2.-
*Peptide Synthases.
Mol Gen Genet 1997 Jan 27;253(4):415-27
pristinamycin I synthetase
EC 6.3.2.-
*Peptide Synthases
Multienzyme Complexes.
J Bacteriol 1997 Feb;179(3):697-704
L-
phenylglycine-
AMP ligase
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
J Bacteriol 1997 Feb;179(3):697-704
4-
dimethylamino-
L-
phenylalanine thioester N-
methylating enzyme
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases
Multienzyme Complexes.
J Bacteriol 1997 Feb;179(3):697-704
SnbC protein, Streptomyces pristinaespiralis
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases
Multienzyme Complexes.
J Bacteriol 1997 Feb;179(3):697-704
SnbA protein, Streptomyces pristinaespiralis
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
J Bacteriol 1997 Feb;179(3):697-704
aspartic acid activating enzyme
EC 6.3.2.-
*Peptide Synthases.
J Biol Chem 247(16):5095;1972
MAPEP1 protein, Microcystis aeruginosa
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
FEMS Microbiol Lett 1996 Jan 15;135(2-3):295-303
SafA protein, Myxococcus xanthus
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
Microbiology 1995 Aug;141( Pt 8):1793-803
alpha-
aminoadipyl-
cysteinyl-
valine synthetase
EC 6.3.2.-
*Peptide Synthases.
J Bacteriol 1986 Nov;168(2):947-52
SyrC protein, Pseudomonas syringae
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
J Bacteriol 1995 Jul;177(14):4009-20
SYRB1 protein, Pseudomonas syringae
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
J Bacteriol 1995 Jul;177(14):4009-20
pyoverdine synthetase protein, Pseudomonas
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
J Bacterial 1995 Jan;177(1):252-8
SDZ 90-
215 synthetase
EC 6.3.2.-
*Multienzyme Complexes
*Peptide Synthases.
Biochem Mol Biol Int 1993 Dec;31(5):797-805
PurC protein, Bacteria
EC 6.3.2.6
*Bacterial Proteins
*Peptide Synthases.
J Bacteriol 1993 Oct 1;175(19):6364-67
peptolide SDZ 214-
103 synthetase
138576-33-7 Synthetase, peptolide
*Multienzyme Complexes
*Peptide Synthases.
J Biol Chem 1993 Sep 25;268(27):20452-65
HC-
toxin synthetase 2
EC 6.3.2.-
*Amino Acid Isomerases
*Peptide Synthases
Ascomycota.
J Biol Chem 1992 Dec 25;267(36):26044-9
lipoate-
protein ligase
EC 6.3.2.-
*Peptide Synthases.
FEBS Lett 1991;295(1-3):13
surfactin synthetase
EC 6.3.2.-
*Bacterial Proteins
*Peptide Synthases.
Biochemistry 1991;30(26):6503
pipecolate-
activating enzyme
EC 6.3.2.-
*Peptide Synthases.
Biochemistry 1991;30(23):5789
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