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Microcystins

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Definition: Cyclic heptapeptides found in MICROCYSTIS and other CYANOBACTERIA. Hepatotoxic and carcinogenic effects have been noted. They are sometimes called cyanotoxins, which should not be confused with chemicals containing a cyano group (CN) which are toxic.     
Pharmacological Action Carcinogens
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(D-Asp3,(E)-Dhb7)-MC-HtyY  0   *Microcystins. J Nat Prod. 2008 Nov;71(11):1881-6
(D-Asp3,(E)-Dhb7)-MC-HtyHty  0   *Microcystins. J Nat Prod. 2008 Nov;71(11):1881-6
microcystin-LR, S-hydroxypropyl-Cys(7)  0   *Microcystins. Toxicon 2009 Feb;53(2):238-45
microcystin-LF  0   *Microcystins Bacterial Toxins. Environ Toxicol 2007 Aug;22(4):436-42
((Dha)7)-microcystin-RR  0   *Microcystins. Toxicon 1992 Sep;30(9):1093-8
(D-Asp(3),D-Glu(OMe)(6))microcystin-RR  0   *Microcystins. J Nat Prod 2004 Mar;67(3):337-42
seco(D-Asp(3))microcystin-RR  0   *Microcystins. J Nat Prod 2004 Mar;67(3):337-42
microcystin synthetase A  EC 6.3.2.-   *Bacterial Proteins *Peptide Synthases Microcystins. Appl Environ Microbiol 2001 Jun;67(6):2810-8
Leu(1)microcystin-LR  0   *Microcystins. Phytochemistry 2000 Nov;55(5):383-7
microcystin-LR, Asp(3)-Dhb(7)  0   *Microcystins. J Nat Prod 1998 Jun 26;61(6):851-3
microcystin-HtyR, Asp(3)-Dhb(7)  0   *Microcystins. J Nat Prod 1998 Jun 26;61(6):851-3
microcystin LL  154037-67-9   *Microcystins. Nat Struct Biol 1995 Feb;2(2):114-6
microcystin LY  123304-10-9 Microcystin LA, 5-L-tyrosine  *Microcystins. Biol Chem Hoppe Seyler 1993 Aug;374(8):635-40
microcystin  77238-39-2   *Microcystins Bacterial Toxins Phosphoprotein Phosphatases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
Biochem J 1992 Dec 1;288(Pt 2):497-501; J Med Chem. 2002 Mar 14;45(6):1151-75
7-desmethylmicrocystin RR  131022-02-1 Cyanoginosin LA, 1-(2,3-didehydroalanine)-3-L-arginine-5-L-arginine  *Microcystins Bacterial Toxins. Z Naturforsch (C) 1992 May-Jun;47(5-6):335-40
(Asp(3)-ADMAAdda(5))microcystin-LHar  141663-36-7   *Microcystins Cyanobacteria Bacterial Toxins. Chem Res Toxicol 1992 Jul-Aug;5(4):464-9
microcystin YM  101043-35-0 Cyanoginosin LA, 3-L-tyrosine-5-L-methionine  *Microcystins Cyanobacteria Toxins, Biological. Toxicol 1991;29(1):43
desmethyl-3-microcystin RR  0   *Microcystins Cyanobacteria Bacterial Toxins Marine Toxins. Appl Environ Microbiol 1990;56(9):2658
microcystin YR  101064-48-6   *Microcystins Cyanobacteria. Biochem Biophys Res Commun 1990;171(2):867
microcystin RR  111755-37-4 Cyanoginosin LA, 3-L-arginine-5-L-arginine  *Microcystins Cyanobacteria. Toxicon 1990;28(1):55
toxin III, cyanobacterium  118389-25-6   *Microcystins Cyanobacteria Bacterial Toxins Marine Toxins. Proc Natl Acad Sci USA 1989;86(3):770
toxin II, cyanobacterium  120011-66-7   *Microcystins Cyanobacteria Marine Toxins. Proc Natl Acad Sci USA 1989;86(3):770
cyanoginosin LR  101043-37-2   *Microcystins Cyanobacteria Bacterial Toxins Marine Toxins Phosphoprotein Phosphatases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors
Toxicol Appl Pharmacol 1988;92(2):248
cyanoginosin-LA  96180-79-9   *Microcystins Cyanobacteria Bacterial Toxins. Toxicon 1986;24(6):543
cyanobacterial toxin  0   *Bacterial Toxins *Marine Toxins *Microcystins Cyanobacteria Neurotoxins. Can J Zoo 56(3):510;1978; Proc West Pharmacol Soc 20:461;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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