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Focal Adhesions

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Definition: An anchoring junction of the cell to a non-cellular substrate. It is composed of a specialized area of the plasma membrane where bundles of the ACTIN CYTOSKELETON terminate and attach to the transmembrane linkers, INTEGRINS, which in turn attach through their extracellular domains to EXTRACELLULAR MATRIX PROTEINS.     
See Also Cell Adhesion 		Other names Plaques, Adhesion; Plaque, Adhesion; Junctions, Cell-Matrix Adherens; Junction, Cell-Matrix Adherens; Focal Contact; Focal Adhesion; Contacts, Focal; Contact, Focal; Cell-Matrix Adherens Junction; Cell Matrix Adherens Junctions; Adhesions, Focal; Adhesion, Focal; Adhesion Plaque; Adherens Junctions, Cell-Matrix; Adherens Junction, Cell-Matrix; Focal Contacts; Cell-Matrix Adherens Junctions; Adhesion Plaques
 
SubstanceCAS Registry & nameCategoriesSource
focal adhesion protein, 52-kDa  0   *Phosphoproteins src Homology Domains Focal Adhesions. J Biol Chem 1997 Sep 12;272(37):23278-84
PTK2B protein, human  EC 2.7.1.-   *Focal Adhesion Kinase 2 Focal Adhesions. Genomics 1996 Mar 15;32(3):484-6

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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