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Indoleamine-Pyrrole 2,3,-Dioxygenase

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Definition: A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is an extrahepatic enzyme that plays a role in metabolism as the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.      Other names Dioxygenase, IDO; Indoleamine-Oxygen 2,3-Oxidoreductase (Decyclizing; Indoleamine 2,3-Dioxygenase; Indolamine-2,3-Dioxygenase; IDO Dioxygenase; Indoleamine 2,3 Dioxygenase; Indolamine 2,3 Dioxygenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
plectosphaeroic acid C  0   *Indole Alkaloids Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors. Org Lett. 2009 Jul 16;11(14):2996-9
plectosphaeroic acid B  0   *Indole Alkaloids Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors. Org Lett. 2009 Jul 16;11(14):2996-9
plectosphaeroic acid A  0   *Indole Alkaloids Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors. Org Lett. 2009 Jul 16;11(14):2996-9
annulin B  0   *Naphthoquinones *Pyrones Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors. J Nat Prod 2006 Oct;69(10):1496-9
brassinin  105748-59-2   *Indoles *Thiocarbamates Indoleamine-Pyrrole 2,3,-Dioxygenase/antagonists & inhibitors. Anticancer Res 1994 May-Jun;14(3A):1209-14

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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