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Protein Kinase C-alpha

More information in Books or onNLM PubMed
Definition: A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.      Other names Serine-Threonine Kinase, PKC-alpha; PKC alpha Serine Threonine Kinase; Protein Kinase C(alpha); Protein Kinase C alpha; PKC-alpha Serine-Threonine Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
bisindolylmaleimide III  0   *Indoles *Maleimides Protein Kinase C-alpha/antagonists & inhibitors. J Proteome Res 2008 Aug;7(8):3490-7
Prkca protein, mouse  EC 2.7.1.37   *Protein Kinase C-alpha.
PRKCA protein, human  EC 2.7.1.37   *Protein Kinase C-alpha.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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