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Kruppel-Like Transcription Factors

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Definition: A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.     
Examples Ikaros Transcription Factor; Sp Transcription Factors 		Other names Transcription Factors, Kruppel-Like; Kruppel Like Transcription Factors; Kruppel Like Factors; Kruppel-Like Factors
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
KLF10 protein, mouse  0   *Kruppel-Like Transcription Factors *Early Growth Response Transcription Factors. Blood. 2011 Dec 8;118(24):6450-60
Klf14 protein, rat  0   *Kruppel-Like Transcription Factors.
Klf14 protein, mouse  0   *Kruppel-Like Transcription Factors.
zinc finger protein 54, mouse  0   *Kruppel-Like Transcription Factors. DNA Cell Biol. 2010 Oct;29(10):589-601
zinc finger protein 1, mouse  0   *Kruppel-Like Transcription Factors. DNA Cell Biol. 2010 Oct;29(10):589-601
GLI3 protein, rat  0   *Kruppel-Like Transcription Factors. Yi Chuan. 2009 Dec;31(12):1214-20)
Klf2 protein, rat  0   *Kruppel-Like Transcription Factors. Mol Cell Biol 1995 Nov;15(11):5957-65
ZBTB5 protein, human  0   *Kruppel-Like Transcription Factors Zinc Fingers. J Biol Chem. 2009 Jul 24;284(30):19856-66
ZNF804A protein, human  0   *Kruppel-Like Transcription Factors Zinc Fingers. Science 2009 May 1;324(5927):605
Klf-1 protein, C elegans  0   *Caenorhabditis elegans Proteins *Kruppel-Like Transcription Factors Zinc Fingers. DNA Cell Biol 2008 Oct;27(10):545-51
Klf3 protein, mouse  0   *Kruppel-Like Transcription Factors. Mol Cell Biol 2008 Jun;28(12):3967-78
Sp6 protein, rat  0   *Kruppel-Like Transcription Factors Zinc Fingers. J Med Invest 2008 Feb;55(1-2):87-98
MNM-2 protein, C elegans  0   *Caenorhabditis elegans Proteins *Kruppel-Like Transcription Factors. Dev Biol 2007 Nov 1;311(1):185-99
ZNF674 protein, human  0   *Kruppel-Like Transcription Factors. Am J Hum Genet. 2006 Feb;78(2)
Klf15 protein, rat  0   *Kruppel-Like Transcription Factors Zinc Fingers. Proc Natl Acad Sci U S A 2007 Apr 24;104(17):7074-9
ZEB1 protein, mouse  0   *Homeodomain Proteins *Kruppel-Like Transcription Factors Zinc Fingers. Nature 2007 Apr 19;446(7138):882-7
GLI4 protein, human  0   *Kruppel-Like Transcription Factors.
Mif1 protein, mouse  0   *Kruppel-Like Transcription Factors. Biochem Biophys Res Commun 2006 Sep 29;348(3):839-49
Zbtb16 protein, mouse  0   *Kruppel-Like Transcription Factors Zinc Fingers.
ZNF12 protein, human  0   *Kruppel-Like Transcription Factors Zinc Fingers. Biochem Biophys Res Commun 2006 Aug 11;346(4):1191-9
ZSCAN21 protein, human  0   *Kruppel-Like Transcription Factors Zinc Fingers. Biochem Biophys Res Commun 2006 Apr 28;343(1):260-8
ZNF506 protein, human  0   *Repressor Proteins *Kruppel-Like Transcription Factors Zinc Fingers. Exp Cell Res 2006 Apr 1;312(6):901-12
ZFP42 protein, human  0   *Kruppel-Like Transcription Factors Zinc Fingers. Int J Mol Med 2005 Dec;16(6):987-92
KLF3 protein, human  0   *Kruppel-Like Transcription Factors.
ZNF18 protein, human  0   *Kruppel-Like Transcription Factors Zinc Fingers. Int J Mol Med 2005 Mar;15(3):545-8
HIC1 protein, zebrafish  0   *Zebrafish Proteins *Kruppel-Like Transcription Factors Genes, Tumor Suppressor Zinc Fingers. Biochim Biophys Acta 2004 Apr 16;1678(1):57-66
ZNF367 protein, human  0   *Kruppel-Like Transcription Factors Zinc Fingers. Biochem J 2004 Dec 15;384(Pt 3):647-53
HIC1 protein, human  0   *Kruppel-Like Transcription Factors. J Mol Diagn 2004 Nov;6(4):326-34
hic2 protein, zebrafish  0   *Tumor Suppressor Proteins *Zebrafish Proteins *Kruppel-Like Transcription Factors.
Klf12 protein, zebrafish  0   *Zebrafish Proteins *Kruppel-Like Transcription Factors.
NKL protein, Xenopus  0   *Nerve Tissue Proteins *Xenopus Proteins *Kruppel-Like Transcription Factors.
Sp6 protein, mouse  0   *Kruppel-Like Transcription Factors Zinc Fingers.
Gli protein, rat  0   *Kruppel-Like Transcription Factors.
Gli protein, mouse  0   *Kruppel-Like Transcription Factors.
Klf2 protein, mouse  0   *Kruppel-Like Transcription Factors.
ZNF8 protein, human  0   *Kruppel-Like Transcription Factors.
ZNF324 protein, human  0   *Kruppel-Like Transcription Factors.
ZNF274 protein, human  0   *Kruppel-Like Transcription Factors.
ZNF101 protein, human  0   *Kruppel-Like Transcription Factors.
Kruppel protein, Drosophila  0   *Drosophila Proteins *Kruppel-Like Transcription Factors.
Kr-h2 protein, Drosophila  0   *Drosophila Proteins *Kruppel-Like Transcription Factors.
Kr-h1 protein, Drosophila  0   *Drosophila Proteins *Kruppel-Like Transcription Factors.
ZNF655 protein, human  0   *Kruppel-Like Transcription Factors Cell Cycle Proteins. O28-38ncogene 2005 Jan 6;24(1):
Klf5 protein, rat  0   *Kruppel-Like Transcription Factors Zinc Fingers.
KLF5 protein, human  0   *Kruppel-Like Transcription Factors Zinc Fingers.
Copeb protein, mouse  0   *Proto-Oncogene Proteins *Kruppel-Like Transcription Factors Zinc Fingers.
Copeb protein, rat  0   *Proto-Oncogene Proteins *Kruppel-Like Transcription Factors Zinc Fingers.
Peg3 protein, rat  0   *Kruppel-Like Transcription Factors Zinc Fingers.
PEG3 protein, human  0   *Kruppel-Like Transcription Factors DNA-Binding Proteins Zinc Fingers.
Mzf1 protein, mouse  0   *Kruppel-Like Transcription Factors Zinc Fingers.
ZFP161 protein, human  0   *Repressor Proteins *Kruppel-Like Transcription Factors Zinc Fingers.
KLF9 protein, human  0   *Kruppel-Like Transcription Factors Zinc Fingers.
Bteb1 protein, mouse  0   *Kruppel-Like Transcription Factors Zinc Fingers.
ZNF253 protein, human  0   *Nuclear Proteins *Repressor Proteins *Kruppel-Like Transcription Factors Zinc Fingers. J Biol Chem 1999 Dec 10;274(50):35741-8
Klf16 protein, mouse  0   *Kruppel-Like Transcription Factors Zinc Fingers.
KLF13 protein, human  0   *Repressor Proteins *Cell Cycle Proteins *Kruppel-Like Transcription Factors Nuclear Proteins Zinc Fingers.
Klf13 protein, mouse  0   *Repressor Proteins *Cell Cycle Proteins *Kruppel-Like Transcription Factors Nuclear Proteins Zinc Fingers.
ZFP37 protein, human  0   *Kruppel-Like Transcription Factors Nerve Tissue Proteins Zinc Fingers.
ZFP62 protein, human  0   *Muscle Proteins *Kruppel-Like Transcription Factors.
KLF7 protein, human  0   *Kruppel-Like Transcription Factors Zinc Fingers. Exp Cell Res 2003 Dec 10;291(2);340-51
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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