encyclopedia of medical concepts
ψ 

Presenilins

More information in Books or onNLM PubMed
Definition: Integral membrane proteins and essential components of the gamma-secretase complex that catalyzes the cleavage of membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. Mutations of presenilins lead to presenile ALZHEIMER DISEASE with onset before age 65 years.     
Examples Presenilin-1; Presenilin-2 		Other names Presenilin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
presenilin, Branchiostoma floridae  0   *Presenilins. Gene 2001 Nov 28;279(2):157-64
Psn protein, Drosophila  0   *Drosophila Proteins *Presenilins. Neuroreport 1997 Feb 10;8(3):665-8
presenilin-beta, protein, Xenopus  0   *Xenopus Proteins *Presenilins. Biochem Biophys Res Commun 1997 Feb 13;231(2):392-6
presenilin-alpha protein, Xenopus  0   *Xenopus Proteins *Presenilins. Biochem Biophys Res Commun 1997 Feb 13;231(2):392-6

To share this definition, click "text" (Facebook, Twitter) or "link" (blog, mail) then paste text link
Ads by Google

Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
This website is accredited by Health On the Net Foundation. Click to verify. We comply with the HONcode standard for trustworthy health information: verify here.
About Reference.MD Privacy